node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BDNF | EGR4 | ENSP00000414303 | ENSP00000445626 | brain-derived neurotrophic factor | early growth response 4; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-GCGGGGGCG-3’ (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity) | 0.854 |
BDNF | GAD1 | ENSP00000414303 | ENSP00000350928 | brain-derived neurotrophic factor | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | 0.658 |
BDNF | NRTN | ENSP00000414303 | ENSP00000302648 | brain-derived neurotrophic factor | neurturin; Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells | 0.648 |
BDNF | SLC12A5 | ENSP00000414303 | ENSP00000387694 | brain-derived neurotrophic factor | solute carrier family 12 (potassium/chloride transporter), member 5; Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons | 0.937 |
CLCN2 | SLC12A5 | ENSP00000265593 | ENSP00000387694 | chloride channel, voltage-sensitive 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport | solute carrier family 12 (potassium/chloride transporter), member 5; Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons | 0.858 |
EGR4 | BDNF | ENSP00000445626 | ENSP00000414303 | early growth response 4; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-GCGGGGGCG-3’ (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity) | brain-derived neurotrophic factor | 0.854 |
EGR4 | NRTN | ENSP00000445626 | ENSP00000302648 | early growth response 4; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-GCGGGGGCG-3’ (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity) | neurturin; Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells | 0.831 |
EGR4 | SLC12A5 | ENSP00000445626 | ENSP00000387694 | early growth response 4; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-GCGGGGGCG-3’ (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity) | solute carrier family 12 (potassium/chloride transporter), member 5; Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons | 0.859 |
GAD1 | BDNF | ENSP00000350928 | ENSP00000414303 | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | brain-derived neurotrophic factor | 0.658 |
GAD1 | SLC12A5 | ENSP00000350928 | ENSP00000387694 | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | solute carrier family 12 (potassium/chloride transporter), member 5; Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons | 0.702 |
NPC2 | SLC12A5 | ENSP00000451112 | ENSP00000387694 | Niemann-Pick disease, type C2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pock [...] | solute carrier family 12 (potassium/chloride transporter), member 5; Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons | 0.788 |
NRTN | BDNF | ENSP00000302648 | ENSP00000414303 | neurturin; Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells | brain-derived neurotrophic factor | 0.648 |
NRTN | EGR4 | ENSP00000302648 | ENSP00000445626 | neurturin; Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells | early growth response 4; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-GCGGGGGCG-3’ (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity) | 0.831 |
NRTN | SLC12A5 | ENSP00000302648 | ENSP00000387694 | neurturin; Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells | solute carrier family 12 (potassium/chloride transporter), member 5; Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons | 0.817 |
SLC12A5 | BDNF | ENSP00000387694 | ENSP00000414303 | solute carrier family 12 (potassium/chloride transporter), member 5; Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons | brain-derived neurotrophic factor | 0.937 |
SLC12A5 | CLCN2 | ENSP00000387694 | ENSP00000265593 | solute carrier family 12 (potassium/chloride transporter), member 5; Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons | chloride channel, voltage-sensitive 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport | 0.858 |
SLC12A5 | EGR4 | ENSP00000387694 | ENSP00000445626 | solute carrier family 12 (potassium/chloride transporter), member 5; Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons | early growth response 4; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-GCGGGGGCG-3’ (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity) | 0.859 |
SLC12A5 | GAD1 | ENSP00000387694 | ENSP00000350928 | solute carrier family 12 (potassium/chloride transporter), member 5; Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | 0.702 |
SLC12A5 | NPC2 | ENSP00000387694 | ENSP00000451112 | solute carrier family 12 (potassium/chloride transporter), member 5; Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons | Niemann-Pick disease, type C2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pock [...] | 0.788 |
SLC12A5 | NRTN | ENSP00000387694 | ENSP00000302648 | solute carrier family 12 (potassium/chloride transporter), member 5; Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons | neurturin; Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells | 0.817 |