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KIF26A KIF26A KIF22 KIF22 KIF4B KIF4B AP2M1 AP2M1 KIF4A KIF4A SH3GL2 SH3GL2 AP2A2 AP2A2 AP2S1 AP2S1 CLTA CLTA AP2B1 AP2B1 AP2A1 AP2A1
"KIF4B" - kinesin family member 4B in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
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experiment edge
experimentally determined
Predicted Interactions
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fusion edge
gene fusions
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gene co-occurrence
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textmining
coexpression edge
co-expression
homology edge
protein homology
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KIF4Bkinesin family member 4B; Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity) (1234 aa)    
Predicted Functional Partners:
KIF22
kinesin family member 22; Kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (665 aa)
      score_image score_image score_image score_image score_image 0.937
KIF26A
kinesin family member 26A; Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity) (1882 aa)
      score_image   score_image score_image score_image 0.930
SH3GL2
SH3-domain GRB2-like 2; Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature (352 aa)
          score_image score_image   0.905
AP2M1
adaptor-related protein complex 2, mu 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a [...] (435 aa)
        score_image score_image     0.902
KIF4A
kinesin family member 4A; Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (1232 aa)
          score_image score_image score_image 0.900
AP2A2
adaptor-related protein complex 2, alpha 2 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as [...] (939 aa)
          score_image     0.900
AP2A1
adaptor-related protein complex 2, alpha 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as [...] (977 aa)
          score_image     0.900
AP2B1
adaptor-related protein complex 2, beta 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as [...] (951 aa)
          score_image     0.900
AP2S1
adaptor-related protein complex 2, sigma 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as [...] (142 aa)
          score_image     0.900
CLTA
clathrin, light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles (248 aa)
          score_image     0.900
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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