MPPED1 protein (Homo sapiens) - STRING network view

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MPPED1

metallophosphoesterase domain containing 1; May have metallophosphoesterase activity (in vitro) (By similarity) (326 aa)

Predicted Functional Partners:

VPS29

0.619

TTC27

0.616

FSHB

0.610

ITM2A

0.541

VPS26A

0.529

PAX6

0.518

VPS35

0.501

VPS26B

0.497

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FSHB	MPPED1	ENSP00000254122	ENSP00000388137	follicle stimulating hormone, beta polypeptide; Stimulates development of follicle and spermatogenesis in the reproductive organs	metallophosphoesterase domain containing 1; May have metallophosphoesterase activity (in vitro) (By similarity)	0.610
FSHB	PAX6	ENSP00000254122	ENSP00000368401	follicle stimulating hormone, beta polypeptide; Stimulates development of follicle and spermatogenesis in the reproductive organs	paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes	0.561
ITM2A	MPPED1	ENSP00000362395	ENSP00000388137	integral membrane protein 2A	metallophosphoesterase domain containing 1; May have metallophosphoesterase activity (in vitro) (By similarity)	0.541
MPPED1	FSHB	ENSP00000388137	ENSP00000254122	metallophosphoesterase domain containing 1; May have metallophosphoesterase activity (in vitro) (By similarity)	follicle stimulating hormone, beta polypeptide; Stimulates development of follicle and spermatogenesis in the reproductive organs	0.610
MPPED1	ITM2A	ENSP00000388137	ENSP00000362395	metallophosphoesterase domain containing 1; May have metallophosphoesterase activity (in vitro) (By similarity)	integral membrane protein 2A	0.541
MPPED1	PAX6	ENSP00000388137	ENSP00000368401	metallophosphoesterase domain containing 1; May have metallophosphoesterase activity (in vitro) (By similarity)	paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes	0.518
MPPED1	TTC27	ENSP00000388137	ENSP00000313953	metallophosphoesterase domain containing 1; May have metallophosphoesterase activity (in vitro) (By similarity)	tetratricopeptide repeat domain 27	0.616
MPPED1	VPS26A	ENSP00000388137	ENSP00000263559	metallophosphoesterase domain containing 1; May have metallophosphoesterase activity (in vitro) (By similarity)	vacuolar protein sorting 26 homolog A (S. pombe); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA)	0.529
MPPED1	VPS26B	ENSP00000388137	ENSP00000281187	metallophosphoesterase domain containing 1; May have metallophosphoesterase activity (in vitro) (By similarity)	vacuolar protein sorting 26 homolog B (S. pombe); Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network (By similarity)	0.497
MPPED1	VPS29	ENSP00000388137	ENSP00000380795	metallophosphoesterase domain containing 1; May have metallophosphoesterase activity (in vitro) (By similarity)	vacuolar protein sorting 29 homolog (S. cerevisiae); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro)	0.619
MPPED1	VPS35	ENSP00000388137	ENSP00000299138	metallophosphoesterase domain containing 1; May have metallophosphoesterase activity (in vitro) (By similarity)	vacuolar protein sorting 35 homolog (S. cerevisiae)	0.501
PAX6	FSHB	ENSP00000368401	ENSP00000254122	paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes	follicle stimulating hormone, beta polypeptide; Stimulates development of follicle and spermatogenesis in the reproductive organs	0.561
PAX6	MPPED1	ENSP00000368401	ENSP00000388137	paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes	metallophosphoesterase domain containing 1; May have metallophosphoesterase activity (in vitro) (By similarity)	0.518
TTC27	MPPED1	ENSP00000313953	ENSP00000388137	tetratricopeptide repeat domain 27	metallophosphoesterase domain containing 1; May have metallophosphoesterase activity (in vitro) (By similarity)	0.616
VPS26A	MPPED1	ENSP00000263559	ENSP00000388137	vacuolar protein sorting 26 homolog A (S. pombe); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA)	metallophosphoesterase domain containing 1; May have metallophosphoesterase activity (in vitro) (By similarity)	0.529
VPS26A	VPS29	ENSP00000263559	ENSP00000380795	vacuolar protein sorting 26 homolog A (S. pombe); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA)	vacuolar protein sorting 29 homolog (S. cerevisiae); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro)	0.999
VPS26A	VPS35	ENSP00000263559	ENSP00000299138	vacuolar protein sorting 26 homolog A (S. pombe); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA)	vacuolar protein sorting 35 homolog (S. cerevisiae)	0.999
VPS26B	MPPED1	ENSP00000281187	ENSP00000388137	vacuolar protein sorting 26 homolog B (S. pombe); Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network (By similarity)	metallophosphoesterase domain containing 1; May have metallophosphoesterase activity (in vitro) (By similarity)	0.497
VPS26B	VPS29	ENSP00000281187	ENSP00000380795	vacuolar protein sorting 26 homolog B (S. pombe); Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network (By similarity)	vacuolar protein sorting 29 homolog (S. cerevisiae); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro)	0.987
VPS26B	VPS35	ENSP00000281187	ENSP00000299138	vacuolar protein sorting 26 homolog B (S. pombe); Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network (By similarity)	vacuolar protein sorting 35 homolog (S. cerevisiae)	0.999

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