ENSG00000249624 protein (Homo sapiens)

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protein of unknown 3D structure

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some 3D structure is known or predicted

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second shell of interactors

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Known Interactions

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Predicted Interactions

gene neighborhood

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Score

ENSG00000249624

Uncharacterized protein (333 aa)

Predicted Functional Partners:

IFNA2

0.836

SOCS7

0.800

IFNE

0.800

IFNA4

0.800

IL10

0.800

IFNA17

0.800

IL28B

0.800

IFNA13

0.800

JAK3

0.800

CSH2

0.800

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSH2	ENSG00000249624	ENSP00000376623	ENSP00000388223	chorionic somatomammotropin hormone 2	Uncharacterized protein	0.800
CSH2	JAK3	ENSP00000376623	ENSP00000391676	chorionic somatomammotropin hormone 2	Janus kinase 3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor [...]	0.800
ENSG00000249624	CSH2	ENSP00000388223	ENSP00000376623	Uncharacterized protein	chorionic somatomammotropin hormone 2	0.800
ENSG00000249624	IFNA13	ENSP00000388223	ENSP00000394494	Uncharacterized protein	interferon, alpha 13	0.800
ENSG00000249624	IFNA17	ENSP00000388223	ENSP00000411940	Uncharacterized protein	interferon, alpha 17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase	0.800
ENSG00000249624	IFNA2	ENSP00000388223	ENSP00000369554	Uncharacterized protein	interferon, alpha 2; Produced by macrophages, IFN-alpha have antiviral activities	0.836
ENSG00000249624	IFNA4	ENSP00000388223	ENSP00000412897	Uncharacterized protein	interferon, alpha 4; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase	0.800
ENSG00000249624	IFNE	ENSP00000388223	ENSP00000418018	Uncharacterized protein	interferon, epsilon	0.800
ENSG00000249624	IL10	ENSP00000388223	ENSP00000412237	Uncharacterized protein	interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells	0.800
ENSG00000249624	IL28B	ENSP00000388223	ENSP00000409000	Uncharacterized protein	interleukin 28B (interferon, lambda 3); Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the [...]	0.800
ENSG00000249624	JAK3	ENSP00000388223	ENSP00000391676	Uncharacterized protein	Janus kinase 3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor [...]	0.800
ENSG00000249624	SOCS7	ENSP00000388223	ENSP00000464034	Uncharacterized protein	suppressor of cytokine signaling 7; Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF- like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of t [...]	0.800
IFNA13	ENSG00000249624	ENSP00000394494	ENSP00000388223	interferon, alpha 13	Uncharacterized protein	0.800
IFNA13	JAK3	ENSP00000394494	ENSP00000391676	interferon, alpha 13	Janus kinase 3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor [...]	0.800
IFNA17	ENSG00000249624	ENSP00000411940	ENSP00000388223	interferon, alpha 17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase	Uncharacterized protein	0.800
IFNA17	IFNA2	ENSP00000411940	ENSP00000369554	interferon, alpha 17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase	interferon, alpha 2; Produced by macrophages, IFN-alpha have antiviral activities	0.900
IFNA17	IFNA4	ENSP00000411940	ENSP00000412897	interferon, alpha 17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase	interferon, alpha 4; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase	0.900
IFNA17	JAK3	ENSP00000411940	ENSP00000391676	interferon, alpha 17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase	Janus kinase 3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor [...]	0.804
IFNA2	ENSG00000249624	ENSP00000369554	ENSP00000388223	interferon, alpha 2; Produced by macrophages, IFN-alpha have antiviral activities	Uncharacterized protein	0.836
IFNA2	IFNA17	ENSP00000369554	ENSP00000411940	interferon, alpha 2; Produced by macrophages, IFN-alpha have antiviral activities	interferon, alpha 17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase	0.900

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