| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATCAY | TSTD1 | ENSP00000390941 | ENSP00000388293 | ataxia, cerebellar, Cayman type; Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1; Possible role in tumorigenesis | 0.467 |
| DPYSL5 | TSTD1 | ENSP00000288699 | ENSP00000388293 | dihydropyrimidinase-like 5; May have a function in neuronal differentiation and/or axon growth | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1; Possible role in tumorigenesis | 0.510 |
| GPHN | TSTD1 | ENSP00000417901 | ENSP00000388293 | gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1; Possible role in tumorigenesis | 0.485 |
| MPST | TSTD1 | ENSP00000380318 | ENSP00000388293 | mercaptopyruvate sulfurtransferase; Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regu [...] | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1; Possible role in tumorigenesis | 0.455 |
| MPST | URM1 | ENSP00000380318 | ENSP00000412922 | mercaptopyruvate sulfurtransferase; Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regu [...] | ubiquitin related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. May also act as an ubiquitin-like protein that is covalently conjugated to other proteins; the relevance of such function is however unclear in vivo | 0.485 |
| PDLIM3 | TSTD1 | ENSP00000284770 | ENSP00000388293 | PDZ and LIM domain 3; May play a role in the organization of actin filament arrays within muscle cells (By similarity) | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1; Possible role in tumorigenesis | 0.483 |
| PRSS8 | TSTD1 | ENSP00000319730 | ENSP00000388293 | protease, serine, 8; Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G) | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1; Possible role in tumorigenesis | 0.458 |
| PTRHD1 | TSTD1 | ENSP00000330389 | ENSP00000388293 | peptidyl-tRNA hydrolase domain containing 1 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1; Possible role in tumorigenesis | 0.547 |
| SMOC2 | TSTD1 | ENSP00000346537 | ENSP00000388293 | SPARC related modular calcium binding 2 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1; Possible role in tumorigenesis | 0.538 |
| TSTD1 | ATCAY | ENSP00000388293 | ENSP00000390941 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1; Possible role in tumorigenesis | ataxia, cerebellar, Cayman type; Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites | 0.467 |
| TSTD1 | DPYSL5 | ENSP00000388293 | ENSP00000288699 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1; Possible role in tumorigenesis | dihydropyrimidinase-like 5; May have a function in neuronal differentiation and/or axon growth | 0.510 |
| TSTD1 | GPHN | ENSP00000388293 | ENSP00000417901 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1; Possible role in tumorigenesis | gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released | 0.485 |
| TSTD1 | MPST | ENSP00000388293 | ENSP00000380318 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1; Possible role in tumorigenesis | mercaptopyruvate sulfurtransferase; Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regu [...] | 0.455 |
| TSTD1 | PDLIM3 | ENSP00000388293 | ENSP00000284770 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1; Possible role in tumorigenesis | PDZ and LIM domain 3; May play a role in the organization of actin filament arrays within muscle cells (By similarity) | 0.483 |
| TSTD1 | PRSS8 | ENSP00000388293 | ENSP00000319730 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1; Possible role in tumorigenesis | protease, serine, 8; Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G) | 0.458 |
| TSTD1 | PTRHD1 | ENSP00000388293 | ENSP00000330389 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1; Possible role in tumorigenesis | peptidyl-tRNA hydrolase domain containing 1 | 0.547 |
| TSTD1 | SMOC2 | ENSP00000388293 | ENSP00000346537 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1; Possible role in tumorigenesis | SPARC related modular calcium binding 2 | 0.538 |
| TSTD1 | URM1 | ENSP00000388293 | ENSP00000412922 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1; Possible role in tumorigenesis | ubiquitin related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. May also act as an ubiquitin-like protein that is covalently conjugated to other proteins; the relevance of such function is however unclear in vivo | 0.467 |
| TSTD1 | WNK2 | ENSP00000388293 | ENSP00000297954 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1; Possible role in tumorigenesis | WNK lysine deficient protein kinase 2; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulati [...] | 0.565 |
| URM1 | MPST | ENSP00000412922 | ENSP00000380318 | ubiquitin related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. May also act as an ubiquitin-like protein that is covalently conjugated to other proteins; the relevance of such function is however unclear in vivo | mercaptopyruvate sulfurtransferase; Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regu [...] | 0.485 |
Share
