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STRINGSTRING
UQCRH UQCRH MUC5B MUC5B TRPC5 TRPC5 RNF24 RNF24 TRPC1 TRPC1 COL18A1 COL18A1 TRPC4 TRPC4 TRPC6 TRPC6 UBC UBC KIF1C KIF1C TRPM2 TRPM2
"RNF24" - ring finger protein 24 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
RNF24ring finger protein 24; May play a role in TRPCs intracellular trafficking (169 aa)    
Predicted Functional Partners:
TRPC6
transient receptor potential cation channel, subfamily C, member 6; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion (931 aa)
        score_image   score_image   0.970
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.876
TRPC4
transient receptor potential cation channel, subfamily C, member 4 (982 aa)
            score_image   0.748
TRPM2
transient receptor potential cation channel, subfamily M, member 2; Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has [...] (1503 aa)
            score_image   0.748
TRPC5
transient receptor potential cation channel, subfamily C, member 5; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion (973 aa)
            score_image   0.744
TRPC1
transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion (759 aa)
            score_image   0.661
MUC5B
mucin 5B, oligomeric mucus/gel-forming (5762 aa)
            score_image   0.649
COL18A1
collagen, type XVIII, alpha 1 (1519 aa)
            score_image   0.636
KIF1C
kinesin family member 1C; Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end- directed motility (1103 aa)
            score_image   0.625
UQCRH
ubiquinol-cytochrome c reductase hinge protein; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1 (91 aa)
      score_image score_image       0.624
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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