node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBFA2T2 | KAT6B | ENSP00000262653 | ENSP00000287239 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | K(lysine) acetyltransferase 6B; Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | 0.726 |
CBFA2T2 | SSFA2 | ENSP00000262653 | ENSP00000388731 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | sperm specific antigen 2 | 0.457 |
COBL | GRB10 | ENSP00000265136 | ENSP00000381793 | cordon-bleu homolog (mouse) | growth factor receptor-bound protein 10 | 0.749 |
COBL | SSFA2 | ENSP00000265136 | ENSP00000388731 | cordon-bleu homolog (mouse) | sperm specific antigen 2 | 0.860 |
GGT7 | SSFA2 | ENSP00000338964 | ENSP00000388731 | gamma-glutamyltransferase 7; Cleaves glutathione conjugates (By similarity) | sperm specific antigen 2 | 0.430 |
GNL3L | NUPL2 | ENSP00000338573 | ENSP00000258742 | guanine nucleotide binding protein-like 3 (nucleolar)-like; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal pr [...] | nucleoporin like 2; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope | 0.489 |
GNL3L | SSFA2 | ENSP00000338573 | ENSP00000388731 | guanine nucleotide binding protein-like 3 (nucleolar)-like; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal pr [...] | sperm specific antigen 2 | 0.411 |
GNL3L | UBC | ENSP00000338573 | ENSP00000344818 | guanine nucleotide binding protein-like 3 (nucleolar)-like; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal pr [...] | ubiquitin C | 0.863 |
GRB10 | COBL | ENSP00000381793 | ENSP00000265136 | growth factor receptor-bound protein 10 | cordon-bleu homolog (mouse) | 0.749 |
GRB10 | SSFA2 | ENSP00000381793 | ENSP00000388731 | growth factor receptor-bound protein 10 | sperm specific antigen 2 | 0.418 |
ITPR1 | SSFA2 | ENSP00000306253 | ENSP00000388731 | inositol 1,4,5-trisphosphate receptor, type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity) | sperm specific antigen 2 | 0.812 |
ITPR1 | UBC | ENSP00000306253 | ENSP00000344818 | inositol 1,4,5-trisphosphate receptor, type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity) | ubiquitin C | 0.902 |
KAT6B | CBFA2T2 | ENSP00000287239 | ENSP00000262653 | K(lysine) acetyltransferase 6B; Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.726 |
KAT6B | SSFA2 | ENSP00000287239 | ENSP00000388731 | K(lysine) acetyltransferase 6B; Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | sperm specific antigen 2 | 0.418 |
KAT6B | UBC | ENSP00000287239 | ENSP00000344818 | K(lysine) acetyltransferase 6B; Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | ubiquitin C | 0.655 |
NUPL2 | GNL3L | ENSP00000258742 | ENSP00000338573 | nucleoporin like 2; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope | guanine nucleotide binding protein-like 3 (nucleolar)-like; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal pr [...] | 0.489 |
NUPL2 | SSFA2 | ENSP00000258742 | ENSP00000388731 | nucleoporin like 2; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope | sperm specific antigen 2 | 0.509 |
NUPL2 | UBC | ENSP00000258742 | ENSP00000344818 | nucleoporin like 2; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope | ubiquitin C | 0.620 |
SSFA2 | CBFA2T2 | ENSP00000388731 | ENSP00000262653 | sperm specific antigen 2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.457 |
SSFA2 | COBL | ENSP00000388731 | ENSP00000265136 | sperm specific antigen 2 | cordon-bleu homolog (mouse) | 0.860 |