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STRINGSTRING
GHSR GHSR GCG GCG TAC1 TAC1 CCK CCK NPS NPS MLN MLN MLNR MLNR OXT OXT NMU NMU GRP GRP NTS NTS
"MLN" - motilin in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
MLNmotilin; Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle (115 aa)    
Predicted Functional Partners:
MLNR
motilin receptor; Receptor for motilin (412 aa)
        score_image score_image score_image   0.995
CCK
cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion (115 aa)
          score_image score_image   0.980
NTS
neurotensin; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle (170 aa)
          score_image score_image   0.980
GHSR
growth hormone secretagogue receptor; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine) (366 aa)
          score_image score_image   0.974
GCG
glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life (180 aa)
          score_image score_image   0.971
TAC1
tachykinin, precursor 1 (129 aa)
          score_image score_image   0.970
GRP
gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity) (148 aa)
          score_image score_image   0.968
NPS
neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) (89 aa)
          score_image score_image   0.956
NMU
neuromedin U; Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder (174 aa)
          score_image score_image   0.947
OXT
oxytocin/neurophysin I prepropeptide; Neurophysin 1 specifically binds oxytocin (125 aa)
          score_image score_image   0.939
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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