| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| G3BP1 | KIAA0664 | ENSP00000348578 | ENSP00000388872 | GTPase activating protein (SH3 domain) binding protein 1; May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3’-UTR. ATP- and magnesium- dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3’ tail or hanging tails at both 5’- and 3’-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in [...] | KIAA0664; Involved in proper cytoplasmic distribution of mitochondria (By similarity) | 0.689 |
| G3BP1 | UBC | ENSP00000348578 | ENSP00000344818 | GTPase activating protein (SH3 domain) binding protein 1; May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3’-UTR. ATP- and magnesium- dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3’ tail or hanging tails at both 5’- and 3’-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in [...] | ubiquitin C | 0.983 |
| G3BP1 | USP10 | ENSP00000348578 | ENSP00000219473 | GTPase activating protein (SH3 domain) binding protein 1; May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3’-UTR. ATP- and magnesium- dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3’ tail or hanging tails at both 5’- and 3’-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in [...] | ubiquitin specific peptidase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability- in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels- mediates deubiquitination of BECN1, a key [...] | 0.999 |
| G3BP2 | KIAA0664 | ENSP00000352738 | ENSP00000388872 | GTPase activating protein (SH3 domain) binding protein 2; Probable scaffold protein that may be involved in mRNA transport (Potential) | KIAA0664; Involved in proper cytoplasmic distribution of mitochondria (By similarity) | 0.689 |
| G3BP2 | UBC | ENSP00000352738 | ENSP00000344818 | GTPase activating protein (SH3 domain) binding protein 2; Probable scaffold protein that may be involved in mRNA transport (Potential) | ubiquitin C | 0.948 |
| G3BP2 | USP10 | ENSP00000352738 | ENSP00000219473 | GTPase activating protein (SH3 domain) binding protein 2; Probable scaffold protein that may be involved in mRNA transport (Potential) | ubiquitin specific peptidase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability- in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels- mediates deubiquitination of BECN1, a key [...] | 0.996 |
| KIAA0664 | G3BP1 | ENSP00000388872 | ENSP00000348578 | KIAA0664; Involved in proper cytoplasmic distribution of mitochondria (By similarity) | GTPase activating protein (SH3 domain) binding protein 1; May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3’-UTR. ATP- and magnesium- dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3’ tail or hanging tails at both 5’- and 3’-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in [...] | 0.689 |
| KIAA0664 | G3BP2 | ENSP00000388872 | ENSP00000352738 | KIAA0664; Involved in proper cytoplasmic distribution of mitochondria (By similarity) | GTPase activating protein (SH3 domain) binding protein 2; Probable scaffold protein that may be involved in mRNA transport (Potential) | 0.689 |
| KIAA0664 | MDN1 | ENSP00000388872 | ENSP00000358400 | KIAA0664; Involved in proper cytoplasmic distribution of mitochondria (By similarity) | MDN1, midasin homolog (yeast); Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (By similarity) | 0.881 |
| KIAA0664 | ME1 | ENSP00000388872 | ENSP00000358719 | KIAA0664; Involved in proper cytoplasmic distribution of mitochondria (By similarity) | malic enzyme 1, NADP(+)-dependent, cytosolic | 0.722 |
| KIAA0664 | ME2 | ENSP00000388872 | ENSP00000321070 | KIAA0664; Involved in proper cytoplasmic distribution of mitochondria (By similarity) | malic enzyme 2, NAD(+)-dependent, mitochondrial | 0.722 |
| KIAA0664 | ME3 | ENSP00000388872 | ENSP00000352657 | KIAA0664; Involved in proper cytoplasmic distribution of mitochondria (By similarity) | malic enzyme 3, NADP(+)-dependent, mitochondrial | 0.722 |
| KIAA0664 | POLR2B | ENSP00000388872 | ENSP00000312735 | KIAA0664; Involved in proper cytoplasmic distribution of mitochondria (By similarity) | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each ot [...] | 0.811 |
| KIAA0664 | PPP4R1 | ENSP00000388872 | ENSP00000383402 | KIAA0664; Involved in proper cytoplasmic distribution of mitochondria (By similarity) | protein phosphatase 4, regulatory subunit 1; Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3 | 0.684 |
| KIAA0664 | UBC | ENSP00000388872 | ENSP00000344818 | KIAA0664; Involved in proper cytoplasmic distribution of mitochondria (By similarity) | ubiquitin C | 0.956 |
| KIAA0664 | USP10 | ENSP00000388872 | ENSP00000219473 | KIAA0664; Involved in proper cytoplasmic distribution of mitochondria (By similarity) | ubiquitin specific peptidase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability- in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels- mediates deubiquitination of BECN1, a key [...] | 0.773 |
| MDN1 | KIAA0664 | ENSP00000358400 | ENSP00000388872 | MDN1, midasin homolog (yeast); Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (By similarity) | KIAA0664; Involved in proper cytoplasmic distribution of mitochondria (By similarity) | 0.881 |
| MDN1 | ME1 | ENSP00000358400 | ENSP00000358719 | MDN1, midasin homolog (yeast); Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (By similarity) | malic enzyme 1, NADP(+)-dependent, cytosolic | 0.577 |
| MDN1 | ME2 | ENSP00000358400 | ENSP00000321070 | MDN1, midasin homolog (yeast); Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (By similarity) | malic enzyme 2, NAD(+)-dependent, mitochondrial | 0.577 |
| MDN1 | ME3 | ENSP00000358400 | ENSP00000352657 | MDN1, midasin homolog (yeast); Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (By similarity) | malic enzyme 3, NADP(+)-dependent, mitochondrial | 0.577 |
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