node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A1BG | CRISP3 | ENSP00000263100 | ENSP00000389026 | alpha-1-B glycoprotein | cysteine-rich secretory protein 3 | 0.937 |
AMACR | CRISP3 | ENSP00000371517 | ENSP00000389026 | alpha-methylacyl-CoA racemase | cysteine-rich secretory protein 3 | 0.412 |
AMACR | HPN | ENSP00000371517 | ENSP00000262626 | alpha-methylacyl-CoA racemase | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | 0.649 |
AMACR | TMPRSS2 | ENSP00000371517 | ENSP00000381588 | alpha-methylacyl-CoA racemase | transmembrane protease, serine 2 | 0.581 |
CRISP3 | A1BG | ENSP00000389026 | ENSP00000263100 | cysteine-rich secretory protein 3 | alpha-1-B glycoprotein | 0.937 |
CRISP3 | AMACR | ENSP00000389026 | ENSP00000371517 | cysteine-rich secretory protein 3 | alpha-methylacyl-CoA racemase | 0.412 |
CRISP3 | DIP2B | ENSP00000389026 | ENSP00000301180 | cysteine-rich secretory protein 3 | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.494 |
CRISP3 | HOPX | ENSP00000389026 | ENSP00000450527 | cysteine-rich secretory protein 3 | HOP homeobox; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor | 0.445 |
CRISP3 | HPN | ENSP00000389026 | ENSP00000262626 | cysteine-rich secretory protein 3 | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | 0.472 |
CRISP3 | KNG1 | ENSP00000389026 | ENSP00000265023 | cysteine-rich secretory protein 3 | kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...] | 0.800 |
CRISP3 | MTDH | ENSP00000389026 | ENSP00000338235 | cysteine-rich secretory protein 3 | metadherin; Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF- kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance | 0.751 |
CRISP3 | TMPRSS2 | ENSP00000389026 | ENSP00000381588 | cysteine-rich secretory protein 3 | transmembrane protease, serine 2 | 0.520 |
DIP2B | CRISP3 | ENSP00000301180 | ENSP00000389026 | DIP2 disco-interacting protein 2 homolog B (Drosophila) | cysteine-rich secretory protein 3 | 0.494 |
HOPX | CRISP3 | ENSP00000450527 | ENSP00000389026 | HOP homeobox; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor | cysteine-rich secretory protein 3 | 0.445 |
HPN | AMACR | ENSP00000262626 | ENSP00000371517 | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | alpha-methylacyl-CoA racemase | 0.649 |
HPN | CRISP3 | ENSP00000262626 | ENSP00000389026 | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | cysteine-rich secretory protein 3 | 0.472 |
KNG1 | CRISP3 | ENSP00000265023 | ENSP00000389026 | kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...] | cysteine-rich secretory protein 3 | 0.800 |
MTDH | CRISP3 | ENSP00000338235 | ENSP00000389026 | metadherin; Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF- kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance | cysteine-rich secretory protein 3 | 0.751 |
TMPRSS2 | AMACR | ENSP00000381588 | ENSP00000371517 | transmembrane protease, serine 2 | alpha-methylacyl-CoA racemase | 0.581 |
TMPRSS2 | CRISP3 | ENSP00000381588 | ENSP00000389026 | transmembrane protease, serine 2 | cysteine-rich secretory protein 3 | 0.520 |