TMCO3 protein (Homo sapiens) - STRING network view

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TMCO3

transmembrane and coiled-coil domains 3; Probable Na(+)/H(+) antiporter (By similarity) (677 aa)

Predicted Functional Partners:

SLC9A6

0.748

SLC9A8

0.748

SLC9A7

0.748

SLC9A9

0.748

SLC9C1

0.748

TMEM117

0.700

SLC9B2

0.680

SLC9B1

0.680

ARL16

0.657

ARL1

0.657

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARL1	TMCO3	ENSP00000261636	ENSP00000389399	ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus	transmembrane and coiled-coil domains 3; Probable Na(+)/H(+) antiporter (By similarity)	0.657
ARL16	TMCO3	ENSP00000380635	ENSP00000389399	ADP-ribosylation factor-like 16	transmembrane and coiled-coil domains 3; Probable Na(+)/H(+) antiporter (By similarity)	0.657
SLC9A6	TMCO3	ENSP00000359729	ENSP00000389399	solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6	transmembrane and coiled-coil domains 3; Probable Na(+)/H(+) antiporter (By similarity)	0.748
SLC9A7	SLC9B1	ENSP00000330320	ENSP00000296422	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7; Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	0.709
SLC9A7	SLC9B2	ENSP00000330320	ENSP00000354574	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7; Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2; Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity)	0.834
SLC9A7	TMCO3	ENSP00000330320	ENSP00000389399	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7; Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis	transmembrane and coiled-coil domains 3; Probable Na(+)/H(+) antiporter (By similarity)	0.748
SLC9A8	SLC9B1	ENSP00000354966	ENSP00000296422	solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	0.652
SLC9A8	SLC9B2	ENSP00000354966	ENSP00000354574	solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2; Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity)	0.592
SLC9A8	TMCO3	ENSP00000354966	ENSP00000389399	solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction	transmembrane and coiled-coil domains 3; Probable Na(+)/H(+) antiporter (By similarity)	0.748
SLC9A9	SLC9B1	ENSP00000320246	ENSP00000296422	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9; May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	0.721
SLC9A9	SLC9B2	ENSP00000320246	ENSP00000354574	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9; May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2; Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity)	0.602
SLC9A9	TMCO3	ENSP00000320246	ENSP00000389399	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9; May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell	transmembrane and coiled-coil domains 3; Probable Na(+)/H(+) antiporter (By similarity)	0.748
SLC9B1	SLC9A7	ENSP00000296422	ENSP00000330320	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7; Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis	0.709
SLC9B1	SLC9A8	ENSP00000296422	ENSP00000354966	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction	0.652
SLC9B1	SLC9A9	ENSP00000296422	ENSP00000320246	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9; May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell	0.721
SLC9B1	SLC9C1	ENSP00000296422	ENSP00000306627	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1; Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity)	0.466
SLC9B1	TMCO3	ENSP00000296422	ENSP00000389399	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	transmembrane and coiled-coil domains 3; Probable Na(+)/H(+) antiporter (By similarity)	0.680
SLC9B2	SLC9A7	ENSP00000354574	ENSP00000330320	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2; Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity)	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7; Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis	0.834
SLC9B2	SLC9A8	ENSP00000354574	ENSP00000354966	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2; Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity)	solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction	0.592
SLC9B2	SLC9A9	ENSP00000354574	ENSP00000320246	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2; Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity)	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9; May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell	0.602

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