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STRINGSTRING
FAM213B FAM213B HPGDS HPGDS PTGDS PTGDS TBXAS1 TBXAS1 PTGS1 PTGS1 PTGES3 PTGES3 PTGS2 PTGS2 PPARA PPARA PTGES2 PTGES2 PTGIS PTGIS PTGES PTGES
"TBXAS1" - thromboxane A synthase 1 in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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TBXAS1thromboxane A synthase 1 (platelet) (580 aa)    
Predicted Functional Partners:
PTGIS
prostaglandin I2 (prostacyclin) synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2) (500 aa)
          score_image score_image   0.981
PTGES
prostaglandin E synthase; Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (152 aa)
          score_image score_image   0.961
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells (599 aa)
          score_image score_image   0.958
PTGES3
prostaglandin E synthase 3 (cytosolic); Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (160 aa)
          score_image score_image   0.951
PTGES2
prostaglandin E synthase 2; Isomerase that catalyzes the conversion of unstable intermediate of prostaglandin E2 H2 (PGH2) into the more stable prostaglandin E2 (PGE2) form. May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear (377 aa)
          score_image score_image   0.948
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity (604 aa)
          score_image score_image   0.944
PTGDS
prostaglandin D2 synthase 21kDa (brain); Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transpor [...] (190 aa)
          score_image score_image   0.938
HPGDS
hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide (199 aa)
          score_image score_image   0.937
FAM213B
family with sequence similarity 213, member B (228 aa)
          score_image score_image   0.905
PPARA
peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16-0/18-1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerizati [...] (468 aa)
            score_image   0.854
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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