CEP44 protein (Homo sapiens) - STRING network view

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CEP44

centrosomal protein 44kDa (399 aa)

Predicted Functional Partners:

L3MBTL2

0.665

CCDC116

0.633

UBC

0.620

PHF20L1

0.556

SPERT

0.524

CDK13

0.467

RNF8

0.443

KDM6A

0.438

SRSF10

0.414

SLTM

0.403

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC116	CEP44	ENSP00000292779	ENSP00000389427	coiled-coil domain containing 116	centrosomal protein 44kDa	0.633
CDK13	CEP44	ENSP00000181839	ENSP00000389427	cyclin-dependent kinase 13	centrosomal protein 44kDa	0.467
CDK13	UBC	ENSP00000181839	ENSP00000344818	cyclin-dependent kinase 13	ubiquitin C	0.645
CEP44	CCDC116	ENSP00000389427	ENSP00000292779	centrosomal protein 44kDa	coiled-coil domain containing 116	0.633
CEP44	CDK13	ENSP00000389427	ENSP00000181839	centrosomal protein 44kDa	cyclin-dependent kinase 13	0.467
CEP44	KDM6A	ENSP00000389427	ENSP00000367203	centrosomal protein 44kDa	lysine (K)-specific demethylase 6A; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of ’Lys-27’ of histone H3 is concomitant with methylation of ’Lys-4’ of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A	0.438
CEP44	L3MBTL2	ENSP00000389427	ENSP00000216237	centrosomal protein 44kDa	l(3)mbt-like 2 (Drosophila); Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated ’Lys-20’ on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on ’Lys-4’, ’Lys-9’ or ’Lys-27’	0.665
CEP44	PHF20L1	ENSP00000389427	ENSP00000378784	centrosomal protein 44kDa	PHD finger protein 20-like 1	0.556
CEP44	RNF8	ENSP00000389427	ENSP00000362578	centrosomal protein 44kDa	ring finger protein 8, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles- by mediating the ’Lys-63’- linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing ’Lys-48’-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the ’Lys-63’-linked ubiquitination of histones H2A and H2AX, thereby promoting th [...]	0.443
CEP44	SLTM	ENSP00000389427	ENSP00000369887	centrosomal protein 44kDa	SAFB-like, transcription modulator	0.403
CEP44	SPERT	ENSP00000389427	ENSP00000309189	centrosomal protein 44kDa	spermatid associated	0.524
CEP44	SRSF10	ENSP00000389427	ENSP00000420195	centrosomal protein 44kDa	serine/arginine-rich splicing factor 10	0.414
CEP44	UBC	ENSP00000389427	ENSP00000344818	centrosomal protein 44kDa	ubiquitin C	0.620
KDM6A	CEP44	ENSP00000367203	ENSP00000389427	lysine (K)-specific demethylase 6A; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of ’Lys-27’ of histone H3 is concomitant with methylation of ’Lys-4’ of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A	centrosomal protein 44kDa	0.438
KDM6A	UBC	ENSP00000367203	ENSP00000344818	lysine (K)-specific demethylase 6A; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of ’Lys-27’ of histone H3 is concomitant with methylation of ’Lys-4’ of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A	ubiquitin C	0.695
L3MBTL2	CEP44	ENSP00000216237	ENSP00000389427	l(3)mbt-like 2 (Drosophila); Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated ’Lys-20’ on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on ’Lys-4’, ’Lys-9’ or ’Lys-27’	centrosomal protein 44kDa	0.665
PHF20L1	CEP44	ENSP00000378784	ENSP00000389427	PHD finger protein 20-like 1	centrosomal protein 44kDa	0.556
PHF20L1	UBC	ENSP00000378784	ENSP00000344818	PHD finger protein 20-like 1	ubiquitin C	0.730
RNF8	CEP44	ENSP00000362578	ENSP00000389427	ring finger protein 8, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles- by mediating the ’Lys-63’- linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing ’Lys-48’-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the ’Lys-63’-linked ubiquitination of histones H2A and H2AX, thereby promoting th [...]	centrosomal protein 44kDa	0.443
RNF8	UBC	ENSP00000362578	ENSP00000344818	ring finger protein 8, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles- by mediating the ’Lys-63’- linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing ’Lys-48’-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the ’Lys-63’-linked ubiquitination of histones H2A and H2AX, thereby promoting th [...]	ubiquitin C	0.980

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