| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C22orf25 | LUZP2 | ENSP00000332721 | ENSP00000336817 | chromosome 22 open reading frame 25 | leucine zipper protein 2 | 0.531 |
| C22orf25 | RNF212 | ENSP00000332721 | ENSP00000389709 | chromosome 22 open reading frame 25 | ring finger protein 212; Key regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover- specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement (By similarity) | 0.622 |
| C22orf25 | SGSM2 | ENSP00000332721 | ENSP00000268989 | chromosome 22 open reading frame 25 | small G protein signaling modulator 2 | 0.499 |
| C22orf25 | SLC39A13 | ENSP00000332721 | ENSP00000354689 | chromosome 22 open reading frame 25 | solute carrier family 39 (zinc transporter), member 13; Acts as a zinc-influx transporter | 0.471 |
| CCNB1IP1 | RNF212 | ENSP00000337396 | ENSP00000389709 | cyclin B1 interacting protein 1, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis | ring finger protein 212; Key regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover- specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement (By similarity) | 0.561 |
| CNTD1 | RNF212 | ENSP00000465204 | ENSP00000389709 | cyclin N-terminal domain containing 1 | ring finger protein 212; Key regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover- specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement (By similarity) | 0.472 |
| LUZP2 | C22orf25 | ENSP00000336817 | ENSP00000332721 | leucine zipper protein 2 | chromosome 22 open reading frame 25 | 0.531 |
| LUZP2 | RNF212 | ENSP00000336817 | ENSP00000389709 | leucine zipper protein 2 | ring finger protein 212; Key regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover- specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement (By similarity) | 0.501 |
| PRDM9 | RNF212 | ENSP00000296682 | ENSP00000389709 | PR domain containing 9; Histone methyltransferase that specifically trimethylates ’Lys-4’ of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity) | ring finger protein 212; Key regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover- specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement (By similarity) | 0.625 |
| RAD51 | RNF212 | ENSP00000372088 | ENSP00000389709 | RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 | ring finger protein 212; Key regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover- specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement (By similarity) | 0.654 |
| RNF212 | C22orf25 | ENSP00000389709 | ENSP00000332721 | ring finger protein 212; Key regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover- specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement (By similarity) | chromosome 22 open reading frame 25 | 0.622 |
| RNF212 | CCNB1IP1 | ENSP00000389709 | ENSP00000337396 | ring finger protein 212; Key regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover- specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement (By similarity) | cyclin B1 interacting protein 1, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis | 0.561 |
| RNF212 | CNTD1 | ENSP00000389709 | ENSP00000465204 | ring finger protein 212; Key regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover- specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement (By similarity) | cyclin N-terminal domain containing 1 | 0.472 |
| RNF212 | LUZP2 | ENSP00000389709 | ENSP00000336817 | ring finger protein 212; Key regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover- specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement (By similarity) | leucine zipper protein 2 | 0.501 |
| RNF212 | PRDM9 | ENSP00000389709 | ENSP00000296682 | ring finger protein 212; Key regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover- specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement (By similarity) | PR domain containing 9; Histone methyltransferase that specifically trimethylates ’Lys-4’ of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity) | 0.625 |
| RNF212 | RAD51 | ENSP00000389709 | ENSP00000372088 | ring finger protein 212; Key regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover- specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement (By similarity) | RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 | 0.654 |
| RNF212 | SGSM2 | ENSP00000389709 | ENSP00000268989 | ring finger protein 212; Key regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover- specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement (By similarity) | small G protein signaling modulator 2 | 0.420 |
| RNF212 | SLC39A13 | ENSP00000389709 | ENSP00000354689 | ring finger protein 212; Key regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover- specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement (By similarity) | solute carrier family 39 (zinc transporter), member 13; Acts as a zinc-influx transporter | 0.407 |
| SGSM2 | C22orf25 | ENSP00000268989 | ENSP00000332721 | small G protein signaling modulator 2 | chromosome 22 open reading frame 25 | 0.499 |
| SGSM2 | RNF212 | ENSP00000268989 | ENSP00000389709 | small G protein signaling modulator 2 | ring finger protein 212; Key regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover- specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement (By similarity) | 0.420 |
Share
