RDH13 protein (Homo sapiens) - STRING network view

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RDH13

retinol dehydrogenase 13 (all-trans/9-cis) (331 aa)

Predicted Functional Partners:

DHRS3

0.727

RPE65

0.658

ACACA

0.581

ACACB

0.581

C14orf177

0.581

MRRF

0.564

SDPR

0.521

ABCA4

0.516

BCO2

0.515

SYT5

0.508

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA4	RDH13	ENSP00000359245	ENSP00000391121	ATP-binding cassette, sub-family A (ABC1), member 4; In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans- retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removi [...]	retinol dehydrogenase 13 (all-trans/9-cis)	0.516
ABCA4	RPE65	ENSP00000359245	ENSP00000262340	ATP-binding cassette, sub-family A (ABC1), member 4; In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans- retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removi [...]	retinal pigment epithelium-specific protein 65kDa; Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis- retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of th [...]	0.770
ACACA	ACACB	ENSP00000344789	ENSP00000341044	acetyl-CoA carboxylase alpha	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	0.999
ACACA	DHRS3	ENSP00000344789	ENSP00000365397	acetyl-CoA carboxylase alpha	dehydrogenase/reductase (SDR family) member 3; Catalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of NADPH	0.581
ACACA	RDH13	ENSP00000344789	ENSP00000391121	acetyl-CoA carboxylase alpha	retinol dehydrogenase 13 (all-trans/9-cis)	0.581
ACACB	ACACA	ENSP00000341044	ENSP00000344789	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	acetyl-CoA carboxylase alpha	0.999
ACACB	DHRS3	ENSP00000341044	ENSP00000365397	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	dehydrogenase/reductase (SDR family) member 3; Catalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of NADPH	0.581
ACACB	RDH13	ENSP00000341044	ENSP00000391121	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	retinol dehydrogenase 13 (all-trans/9-cis)	0.581
BCO2	RDH13	ENSP00000350314	ENSP00000391121	beta-carotene oxygenase 2; Asymmetrically cleaves beta-carotene at the 9’,10’ double bond resulting in the formation of beta-apo-10’-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects	retinol dehydrogenase 13 (all-trans/9-cis)	0.515
C14orf177	RDH13	ENSP00000321360	ENSP00000391121	chromosome 14 open reading frame 177	retinol dehydrogenase 13 (all-trans/9-cis)	0.581
DHRS3	ACACA	ENSP00000365397	ENSP00000344789	dehydrogenase/reductase (SDR family) member 3; Catalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of NADPH	acetyl-CoA carboxylase alpha	0.581
DHRS3	ACACB	ENSP00000365397	ENSP00000341044	dehydrogenase/reductase (SDR family) member 3; Catalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of NADPH	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	0.581
DHRS3	RDH13	ENSP00000365397	ENSP00000391121	dehydrogenase/reductase (SDR family) member 3; Catalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of NADPH	retinol dehydrogenase 13 (all-trans/9-cis)	0.727
MRRF	RDH13	ENSP00000343867	ENSP00000391121	mitochondrial ribosome recycling factor	retinol dehydrogenase 13 (all-trans/9-cis)	0.564
RDH13	ABCA4	ENSP00000391121	ENSP00000359245	retinol dehydrogenase 13 (all-trans/9-cis)	ATP-binding cassette, sub-family A (ABC1), member 4; In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans- retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removi [...]	0.516
RDH13	ACACA	ENSP00000391121	ENSP00000344789	retinol dehydrogenase 13 (all-trans/9-cis)	acetyl-CoA carboxylase alpha	0.581
RDH13	ACACB	ENSP00000391121	ENSP00000341044	retinol dehydrogenase 13 (all-trans/9-cis)	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	0.581
RDH13	BCO2	ENSP00000391121	ENSP00000350314	retinol dehydrogenase 13 (all-trans/9-cis)	beta-carotene oxygenase 2; Asymmetrically cleaves beta-carotene at the 9’,10’ double bond resulting in the formation of beta-apo-10’-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects	0.515
RDH13	C14orf177	ENSP00000391121	ENSP00000321360	retinol dehydrogenase 13 (all-trans/9-cis)	chromosome 14 open reading frame 177	0.581
RDH13	DHRS3	ENSP00000391121	ENSP00000365397	retinol dehydrogenase 13 (all-trans/9-cis)	dehydrogenase/reductase (SDR family) member 3; Catalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of NADPH	0.727

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