SEPT9 protein (Homo sapiens) - STRING network view

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SEPT9

septin 9 (586 aa)

Predicted Functional Partners:

SKOR2

0.647

C9orf69

0.645

BRSK2

0.623

BRSK1

0.623

OVCA2

0.606

ENSG00000214014

0.606

GP9

0.562

NXPH2

0.561

GAS7

0.553

FCHO2

0.531

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRSK1	SEPT9	ENSP00000310649	ENSP00000391249	BR serine/threonine kinase 1; Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regulate WEE1 activit [...]	septin 9	0.623
BRSK2	SEPT9	ENSP00000310697	ENSP00000391249	BR serine/threonine kinase 2; Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regu [...]	septin 9	0.623
C9orf69	GAS7	ENSP00000453019	ENSP00000407552	chromosome 9 open reading frame 69; Plays a role in cell proliferation by promoting progression into S phase. Promotes human herpesvirus 1 (HHV-1) proliferation	growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons	0.424
C9orf69	SEPT9	ENSP00000453019	ENSP00000391249	chromosome 9 open reading frame 69; Plays a role in cell proliferation by promoting progression into S phase. Promotes human herpesvirus 1 (HHV-1) proliferation	septin 9	0.645
ENSG00000214014	NXPH2	ENSP00000263084	ENSP00000272641	Ovarian cancer-associated gene 2 protein	neurexophilin 2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors (Potential)	0.608
ENSG00000214014	SEPT9	ENSP00000263084	ENSP00000391249	Ovarian cancer-associated gene 2 protein	septin 9	0.606
FCHO2	SEPT9	ENSP00000393776	ENSP00000391249	FCH domain only 2; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocyto [...]	septin 9	0.531
GAS7	C9orf69	ENSP00000407552	ENSP00000453019	growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons	chromosome 9 open reading frame 69; Plays a role in cell proliferation by promoting progression into S phase. Promotes human herpesvirus 1 (HHV-1) proliferation	0.424
GAS7	SEPT9	ENSP00000407552	ENSP00000391249	growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons	septin 9	0.553
GP9	SEPT9	ENSP00000303942	ENSP00000391249	glycoprotein IX (platelet); The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib	septin 9	0.562
NXPH2	ENSG00000214014	ENSP00000272641	ENSP00000263084	neurexophilin 2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors (Potential)	Ovarian cancer-associated gene 2 protein	0.608
NXPH2	OVCA2	ENSP00000272641	ENSP00000461388	neurexophilin 2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors (Potential)	ovarian tumor suppressor candidate 2	0.608
NXPH2	SEPT9	ENSP00000272641	ENSP00000391249	neurexophilin 2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors (Potential)	septin 9	0.561
OVCA2	NXPH2	ENSP00000461388	ENSP00000272641	ovarian tumor suppressor candidate 2	neurexophilin 2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors (Potential)	0.608
OVCA2	SEPT9	ENSP00000461388	ENSP00000391249	ovarian tumor suppressor candidate 2	septin 9	0.606
SEPT9	BRSK1	ENSP00000391249	ENSP00000310649	septin 9	BR serine/threonine kinase 1; Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regulate WEE1 activit [...]	0.623
SEPT9	BRSK2	ENSP00000391249	ENSP00000310697	septin 9	BR serine/threonine kinase 2; Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regu [...]	0.623
SEPT9	C9orf69	ENSP00000391249	ENSP00000453019	septin 9	chromosome 9 open reading frame 69; Plays a role in cell proliferation by promoting progression into S phase. Promotes human herpesvirus 1 (HHV-1) proliferation	0.645
SEPT9	ENSG00000214014	ENSP00000391249	ENSP00000263084	septin 9	Ovarian cancer-associated gene 2 protein	0.606
SEPT9	FCHO2	ENSP00000391249	ENSP00000393776	septin 9	FCH domain only 2; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocyto [...]	0.531

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