node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDK5 | PARK2 | ENSP00000419782 | ENSP00000355865 | cyclin-dependent kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neurona [...] | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | 0.717 |
CDK5 | SEPT5 | ENSP00000419782 | ENSP00000391311 | cyclin-dependent kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neurona [...] | septin 5; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity) | 0.877 |
CDK5 | STX1A | ENSP00000419782 | ENSP00000222812 | cyclin-dependent kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neurona [...] | syntaxin 1A (brain) | 0.833 |
PARK2 | CDK5 | ENSP00000355865 | ENSP00000419782 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | cyclin-dependent kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neurona [...] | 0.717 |
PARK2 | SEPT5 | ENSP00000355865 | ENSP00000391311 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | septin 5; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity) | 0.994 |
SEPT1 | SEPT10 | ENSP00000460441 | ENSP00000380824 | septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | septin 10; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential) | 0.716 |
SEPT1 | SEPT11 | ENSP00000460441 | ENSP00000264893 | septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | septin 11; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy | 0.717 |
SEPT1 | SEPT14 | ENSP00000460441 | ENSP00000373627 | septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | septin 14; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | 0.869 |
SEPT1 | SEPT2 | ENSP00000460441 | ENSP00000353157 | septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | septin 2; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongat [...] | 0.800 |
SEPT1 | SEPT5 | ENSP00000460441 | ENSP00000391311 | septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | septin 5; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity) | 0.919 |
SEPT1 | SEPT6 | ENSP00000460441 | ENSP00000341524 | septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | septin 6; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication | 0.972 |
SEPT1 | SEPT8 | ENSP00000460441 | ENSP00000367991 | septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | septin 8; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion | 0.718 |
SEPT1 | STX1A | ENSP00000460441 | ENSP00000222812 | septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | syntaxin 1A (brain) | 0.608 |
SEPT10 | SEPT1 | ENSP00000380824 | ENSP00000460441 | septin 10; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential) | septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | 0.716 |
SEPT10 | SEPT2 | ENSP00000380824 | ENSP00000353157 | septin 10; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential) | septin 2; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongat [...] | 0.715 |
SEPT10 | SEPT5 | ENSP00000380824 | ENSP00000391311 | septin 10; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential) | septin 5; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity) | 0.952 |
SEPT10 | STX1A | ENSP00000380824 | ENSP00000222812 | septin 10; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential) | syntaxin 1A (brain) | 0.701 |
SEPT11 | SEPT1 | ENSP00000264893 | ENSP00000460441 | septin 11; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy | septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | 0.717 |
SEPT11 | SEPT2 | ENSP00000264893 | ENSP00000353157 | septin 11; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy | septin 2; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongat [...] | 0.881 |
SEPT11 | SEPT5 | ENSP00000264893 | ENSP00000391311 | septin 11; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy | septin 5; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity) | 0.974 |