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STRINGSTRING
PARK2 PARK2 SEPT6 SEPT6 SEPT10 SEPT10 CDK5 CDK5 SEPT5 SEPT5 SEPT1 SEPT1 STX1A STX1A SEPT2 SEPT2 SEPT8 SEPT8 SEPT11 SEPT11 SEPT14 SEPT14
"SEPT5" - septin 5 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
SEPT5septin 5; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity) (369 aa)    
Predicted Functional Partners:
PARK2
parkinson protein 2, E3 ubiquitin protein ligase (parkin) (465 aa)
        score_image   score_image   0.994
SEPT8
septin 8; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (483 aa)
      score_image score_image score_image score_image score_image 0.989
SEPT2
septin 2; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongat [...] (361 aa)
        score_image score_image score_image score_image 0.989
SEPT6
septin 6; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication (434 aa)
      score_image score_image score_image score_image score_image 0.988
SEPT11
septin 11; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy (429 aa)
      score_image score_image score_image score_image score_image 0.974
SEPT10
septin 10; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential) (454 aa)
      score_image score_image score_image score_image score_image 0.952
SEPT1
septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) (367 aa)
        score_image score_image score_image score_image 0.919
CDK5
cyclin-dependent kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neurona [...] (292 aa)
        score_image   score_image   0.877
SEPT14
septin 14; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) (432 aa)
      score_image score_image score_image score_image score_image 0.871
STX1A
syntaxin 1A (brain) (288 aa)
        score_image   score_image   0.849
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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