node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGR2 | AREG | ENSP00000391490 | ENSP00000264487 | anterior gradient 2 homolog (Xenopus laevis); Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth | amphiregulin | 0.821 |
AGR2 | CD59 | ENSP00000391490 | ENSP00000340210 | anterior gradient 2 homolog (Xenopus laevis); Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth | CD59 molecule, complement regulatory protein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase | 0.603 |
AGR2 | DAG1 | ENSP00000391490 | ENSP00000312435 | anterior gradient 2 homolog (Xenopus laevis); Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | 0.849 |
AGR2 | FABP2 | ENSP00000391490 | ENSP00000274024 | anterior gradient 2 homolog (Xenopus laevis); Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth | fatty acid binding protein 2, intestinal; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor | 0.557 |
AGR2 | LYPD3 | ENSP00000391490 | ENSP00000244333 | anterior gradient 2 homolog (Xenopus laevis); Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth | LY6/PLAUR domain containing 3; Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression | 0.989 |
AGR2 | MUC2 | ENSP00000391490 | ENSP00000415183 | anterior gradient 2 homolog (Xenopus laevis); Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth | mucin 2, oligomeric mucus/gel-forming; Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer | 0.932 |
AGR2 | NUP62CL | ENSP00000391490 | ENSP00000361544 | anterior gradient 2 homolog (Xenopus laevis); Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth | nucleoporin 62kDa C-terminal like | 0.590 |
AGR2 | POM121 | ENSP00000391490 | ENSP00000257622 | anterior gradient 2 homolog (Xenopus laevis); Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth | POM121 transmembrane nucleoporin | 0.500 |
AGR2 | RUVBL2 | ENSP00000391490 | ENSP00000473172 | anterior gradient 2 homolog (Xenopus laevis); Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth | RuvB-like 2 (E. coli); Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5’ to 3’) activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity | 0.819 |
AGR2 | SFI1 | ENSP00000391490 | ENSP00000383145 | anterior gradient 2 homolog (Xenopus laevis); Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth | Sfi1 homolog, spindle assembly associated (yeast) | 0.599 |
AREG | AGR2 | ENSP00000264487 | ENSP00000391490 | amphiregulin | anterior gradient 2 homolog (Xenopus laevis); Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth | 0.821 |
CD59 | AGR2 | ENSP00000340210 | ENSP00000391490 | CD59 molecule, complement regulatory protein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase | anterior gradient 2 homolog (Xenopus laevis); Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth | 0.603 |
DAG1 | AGR2 | ENSP00000312435 | ENSP00000391490 | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | anterior gradient 2 homolog (Xenopus laevis); Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth | 0.849 |
DAG1 | LYPD3 | ENSP00000312435 | ENSP00000244333 | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | LY6/PLAUR domain containing 3; Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression | 0.663 |
FABP2 | AGR2 | ENSP00000274024 | ENSP00000391490 | fatty acid binding protein 2, intestinal; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor | anterior gradient 2 homolog (Xenopus laevis); Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth | 0.557 |
LYPD3 | AGR2 | ENSP00000244333 | ENSP00000391490 | LY6/PLAUR domain containing 3; Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression | anterior gradient 2 homolog (Xenopus laevis); Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth | 0.989 |
LYPD3 | DAG1 | ENSP00000244333 | ENSP00000312435 | LY6/PLAUR domain containing 3; Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | 0.663 |
MUC2 | AGR2 | ENSP00000415183 | ENSP00000391490 | mucin 2, oligomeric mucus/gel-forming; Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer | anterior gradient 2 homolog (Xenopus laevis); Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth | 0.932 |
NUP62CL | AGR2 | ENSP00000361544 | ENSP00000391490 | nucleoporin 62kDa C-terminal like | anterior gradient 2 homolog (Xenopus laevis); Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth | 0.590 |
POM121 | AGR2 | ENSP00000257622 | ENSP00000391490 | POM121 transmembrane nucleoporin | anterior gradient 2 homolog (Xenopus laevis); Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth | 0.500 |