ENSG00000250264 protein (Homo sapiens)

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protein of unknown 3D structure

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ENSG00000250264

Uncharacterized protein (843 aa)

Predicted Functional Partners:

TOP2A

0.557

TOP2B

0.557

PSMB9

0.552

VPS37B

0.503

OGFOD2

0.489

ABCG8

0.449

PIKFYVE

0.424

PSMB10

0.415

RIPK4

0.413

PSMB7

0.402

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCG8	ENSG00000250264	ENSP00000272286	ENSP00000391806	ATP-binding cassette, sub-family G (WHITE), member 8; Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile	Uncharacterized protein	0.449
ENSG00000250264	ABCG8	ENSP00000391806	ENSP00000272286	Uncharacterized protein	ATP-binding cassette, sub-family G (WHITE), member 8; Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile	0.449
ENSG00000250264	OGFOD2	ENSP00000391806	ENSP00000380544	Uncharacterized protein	2-oxoglutarate and iron-dependent oxygenase domain containing 2	0.489
ENSG00000250264	PIKFYVE	ENSP00000391806	ENSP00000264380	Uncharacterized protein	phosphoinositide kinase, FYVE finger containing; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes	0.424
ENSG00000250264	PSMB10	ENSP00000391806	ENSP00000351314	Uncharacterized protein	proteasome (prosome, macropain) subunit, beta type, 10; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides	0.415
ENSG00000250264	PSMB7	ENSP00000391806	ENSP00000259457	Uncharacterized protein	proteasome (prosome, macropain) subunit, beta type, 7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the trypsin-like activity	0.402
ENSG00000250264	PSMB9	ENSP00000391806	ENSP00000363993	Uncharacterized protein	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)	0.552
ENSG00000250264	RIPK4	ENSP00000391806	ENSP00000332454	Uncharacterized protein	receptor-interacting serine-threonine kinase 4; Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation	0.413
ENSG00000250264	TOP2A	ENSP00000391806	ENSP00000411532	Uncharacterized protein	topoisomerase (DNA) II alpha 170kDa	0.557
ENSG00000250264	TOP2B	ENSP00000391806	ENSP00000396704	Uncharacterized protein	topoisomerase (DNA) II beta 180kDa; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene	0.557
ENSG00000250264	VPS37B	ENSP00000391806	ENSP00000267202	Uncharacterized protein	vacuolar protein sorting 37 homolog B (S. cerevisiae); Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation	0.503
OGFOD2	ENSG00000250264	ENSP00000380544	ENSP00000391806	2-oxoglutarate and iron-dependent oxygenase domain containing 2	Uncharacterized protein	0.489
OGFOD2	VPS37B	ENSP00000380544	ENSP00000267202	2-oxoglutarate and iron-dependent oxygenase domain containing 2	vacuolar protein sorting 37 homolog B (S. cerevisiae); Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation	0.621
PIKFYVE	ENSG00000250264	ENSP00000264380	ENSP00000391806	phosphoinositide kinase, FYVE finger containing; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes	Uncharacterized protein	0.424
PIKFYVE	PSMB10	ENSP00000264380	ENSP00000351314	phosphoinositide kinase, FYVE finger containing; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes	proteasome (prosome, macropain) subunit, beta type, 10; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides	0.409
PIKFYVE	PSMB7	ENSP00000264380	ENSP00000259457	phosphoinositide kinase, FYVE finger containing; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes	proteasome (prosome, macropain) subunit, beta type, 7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the trypsin-like activity	0.409
PIKFYVE	RIPK4	ENSP00000264380	ENSP00000332454	phosphoinositide kinase, FYVE finger containing; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes	receptor-interacting serine-threonine kinase 4; Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation	0.656
PIKFYVE	TOP2A	ENSP00000264380	ENSP00000411532	phosphoinositide kinase, FYVE finger containing; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes	topoisomerase (DNA) II alpha 170kDa	0.659
PIKFYVE	TOP2B	ENSP00000264380	ENSP00000396704	phosphoinositide kinase, FYVE finger containing; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes	topoisomerase (DNA) II beta 180kDa; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene	0.659
PSMB10	ENSG00000250264	ENSP00000351314	ENSP00000391806	proteasome (prosome, macropain) subunit, beta type, 10; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides	Uncharacterized protein	0.415

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