AGAP4 protein (Homo sapiens) - STRING network view

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AGAP4

ArfGAP with GTPase domain, ankyrin repeat and PH domain 4; Putative GTPase-activating protein (Potential) (663 aa)

Predicted Functional Partners:

ECD

0.700

ZNF793

0.581

TMBIM1

0.558

FAIM2

0.547

ARL16

0.513

ANKRD28

0.512

ANKRD52

0.512

SH3TC1

0.504

RHOA

0.492

RHOC

0.492

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGAP4	ANKRD28	ENSP00000392513	ENSP00000382379	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4; Putative GTPase-activating protein (Potential)	ankyrin repeat domain 28; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation	0.512
AGAP4	ANKRD52	ENSP00000392513	ENSP00000267116	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4; Putative GTPase-activating protein (Potential)	ankyrin repeat domain 52; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates	0.512
AGAP4	ARL16	ENSP00000392513	ENSP00000380635	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4; Putative GTPase-activating protein (Potential)	ADP-ribosylation factor-like 16	0.513
AGAP4	ECD	ENSP00000392513	ENSP00000401566	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4; Putative GTPase-activating protein (Potential)	ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes	0.700
AGAP4	FAIM2	ENSP00000392513	ENSP00000321951	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4; Putative GTPase-activating protein (Potential)	Fas apoptotic inhibitory molecule 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development	0.547
AGAP4	RHOA	ENSP00000392513	ENSP00000400175	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4; Putative GTPase-activating protein (Potential)	ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...]	0.492
AGAP4	RHOC	ENSP00000392513	ENSP00000285735	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4; Putative GTPase-activating protein (Potential)	ras homolog family member C; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells	0.492
AGAP4	SH3TC1	ENSP00000392513	ENSP00000245105	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4; Putative GTPase-activating protein (Potential)	SH3 domain and tetratricopeptide repeats 1	0.504
AGAP4	TMBIM1	ENSP00000392513	ENSP00000258412	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4; Putative GTPase-activating protein (Potential)	transmembrane BAX inhibitor motif containing 1; Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling	0.558
AGAP4	ZNF793	ENSP00000392513	ENSP00000396402	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4; Putative GTPase-activating protein (Potential)	zinc finger protein 793; May be involved in transcriptional regulation	0.581
ANKRD28	AGAP4	ENSP00000382379	ENSP00000392513	ankyrin repeat domain 28; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4; Putative GTPase-activating protein (Potential)	0.512
ANKRD28	FAIM2	ENSP00000382379	ENSP00000321951	ankyrin repeat domain 28; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation	Fas apoptotic inhibitory molecule 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development	0.439
ANKRD52	AGAP4	ENSP00000267116	ENSP00000392513	ankyrin repeat domain 52; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4; Putative GTPase-activating protein (Potential)	0.512
ANKRD52	FAIM2	ENSP00000267116	ENSP00000321951	ankyrin repeat domain 52; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates	Fas apoptotic inhibitory molecule 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development	0.580
ANKRD52	TMBIM1	ENSP00000267116	ENSP00000258412	ankyrin repeat domain 52; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates	transmembrane BAX inhibitor motif containing 1; Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling	0.465
ARL16	AGAP4	ENSP00000380635	ENSP00000392513	ADP-ribosylation factor-like 16	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4; Putative GTPase-activating protein (Potential)	0.513
ECD	AGAP4	ENSP00000401566	ENSP00000392513	ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4; Putative GTPase-activating protein (Potential)	0.700
FAIM2	AGAP4	ENSP00000321951	ENSP00000392513	Fas apoptotic inhibitory molecule 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4; Putative GTPase-activating protein (Potential)	0.547
FAIM2	ANKRD28	ENSP00000321951	ENSP00000382379	Fas apoptotic inhibitory molecule 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development	ankyrin repeat domain 28; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation	0.439
FAIM2	ANKRD52	ENSP00000321951	ENSP00000267116	Fas apoptotic inhibitory molecule 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development	ankyrin repeat domain 52; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates	0.580

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