node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDK20 | TTLL3 | ENSP00000322343 | ENSP00000392549 | cyclin-dependent kinase 20; Required for high-level Shh responses in the developing neural tube. Together with BROMI, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue ’Thr-160’ | tubulin tyrosine ligase-like family, member 3; Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction | 0.593 |
CORO1B | TTLL3 | ENSP00000340211 | ENSP00000392549 | coronin, actin binding protein, 1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity) | tubulin tyrosine ligase-like family, member 3; Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction | 0.519 |
DCP1B | TBC1D24 | ENSP00000280665 | ENSP00000293970 | DCP1 decapping enzyme homolog B (S. cerevisiae); May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5’-phosphorylated mRNA fragment and 7m-GDP (By similarity) | TBC1 domain family, member 24; May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function | 0.615 |
DCP1B | TTLL3 | ENSP00000280665 | ENSP00000392549 | DCP1 decapping enzyme homolog B (S. cerevisiae); May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5’-phosphorylated mRNA fragment and 7m-GDP (By similarity) | tubulin tyrosine ligase-like family, member 3; Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction | 0.604 |
FAM5C | MON1B | ENSP00000356432 | ENSP00000248248 | family with sequence similarity 5, member C | MON1 homolog B (yeast) | 0.659 |
FAM5C | TBC1D24 | ENSP00000356432 | ENSP00000293970 | family with sequence similarity 5, member C | TBC1 domain family, member 24; May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function | 0.648 |
FAM5C | TTLL3 | ENSP00000356432 | ENSP00000392549 | family with sequence similarity 5, member C | tubulin tyrosine ligase-like family, member 3; Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction | 0.663 |
MON1B | FAM5C | ENSP00000248248 | ENSP00000356432 | MON1 homolog B (yeast) | family with sequence similarity 5, member C | 0.659 |
MON1B | TBC1D24 | ENSP00000248248 | ENSP00000293970 | MON1 homolog B (yeast) | TBC1 domain family, member 24; May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function | 0.619 |
MON1B | TTLL3 | ENSP00000248248 | ENSP00000392549 | MON1 homolog B (yeast) | tubulin tyrosine ligase-like family, member 3; Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction | 0.629 |
POP4 | TTLL3 | ENSP00000465213 | ENSP00000392549 | processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P | tubulin tyrosine ligase-like family, member 3; Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction | 0.433 |
SPDYA | TTLL3 | ENSP00000335628 | ENSP00000392549 | speedy homolog A (Xenopus laevis); Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1, CDK2 and CDKN1B/KIP1. Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA damage process through activation of CDK2 | tubulin tyrosine ligase-like family, member 3; Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction | 0.565 |
TBC1D24 | DCP1B | ENSP00000293970 | ENSP00000280665 | TBC1 domain family, member 24; May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function | DCP1 decapping enzyme homolog B (S. cerevisiae); May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5’-phosphorylated mRNA fragment and 7m-GDP (By similarity) | 0.615 |
TBC1D24 | FAM5C | ENSP00000293970 | ENSP00000356432 | TBC1 domain family, member 24; May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function | family with sequence similarity 5, member C | 0.648 |
TBC1D24 | MON1B | ENSP00000293970 | ENSP00000248248 | TBC1 domain family, member 24; May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function | MON1 homolog B (yeast) | 0.619 |
TBC1D24 | TTLL3 | ENSP00000293970 | ENSP00000392549 | TBC1 domain family, member 24; May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function | tubulin tyrosine ligase-like family, member 3; Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction | 0.571 |
TTC26 | TTC30B | ENSP00000419279 | ENSP00000386181 | tetratricopeptide repeat domain 26; May play a critical role in ciliogenesis and normal cilia function (By similarity) | tetratricopeptide repeat domain 30B; Required for polyglutamylation of axonemal tubulin (By similarity). Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity) | 0.552 |
TTC26 | TTLL3 | ENSP00000419279 | ENSP00000392549 | tetratricopeptide repeat domain 26; May play a critical role in ciliogenesis and normal cilia function (By similarity) | tubulin tyrosine ligase-like family, member 3; Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction | 0.438 |
TTC30B | TTC26 | ENSP00000386181 | ENSP00000419279 | tetratricopeptide repeat domain 30B; Required for polyglutamylation of axonemal tubulin (By similarity). Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity) | tetratricopeptide repeat domain 26; May play a critical role in ciliogenesis and normal cilia function (By similarity) | 0.552 |
TTC30B | TTLL3 | ENSP00000386181 | ENSP00000392549 | tetratricopeptide repeat domain 30B; Required for polyglutamylation of axonemal tubulin (By similarity). Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity) | tubulin tyrosine ligase-like family, member 3; Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction | 0.437 |