POTEI protein (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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Known Interactions

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Score

POTEI

POTE ankyrin domain family, member I (1075 aa)

Predicted Functional Partners:

WDR1

0.976

BRPF3

0.962

TUBA4A

0.953

TLN1

0.914

SOD1

0.906

PLEK

0.905

TTN

0.905

VCL

0.905

HABP4

0.900

PHLPP2

0.890

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRPF3	HABP4	ENSP00000350267	ENSP00000364398	bromodomain and PHD finger containing, 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity	hyaluronan binding protein 4; May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription	0.900
BRPF3	PLEK	ENSP00000350267	ENSP00000234313	bromodomain and PHD finger containing, 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity	pleckstrin; Major protein kinase C substrate of platelets	0.900
BRPF3	POTEI	ENSP00000350267	ENSP00000392718	bromodomain and PHD finger containing, 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity	POTE ankyrin domain family, member I	0.962
BRPF3	SOD1	ENSP00000350267	ENSP00000270142	bromodomain and PHD finger containing, 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity	superoxide dismutase 1, soluble; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)	0.901
BRPF3	TLN1	ENSP00000350267	ENSP00000316029	bromodomain and PHD finger containing, 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity	talin 1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity)	0.900
BRPF3	TTN	ENSP00000350267	ENSP00000343764	bromodomain and PHD finger containing, 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity	titin	0.900
BRPF3	TUBA4A	ENSP00000350267	ENSP00000248437	bromodomain and PHD finger containing, 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity	tubulin, alpha 4a; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)	0.905
BRPF3	VCL	ENSP00000350267	ENSP00000211998	bromodomain and PHD finger containing, 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity	vinculin; Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion	0.900
BRPF3	WDR1	ENSP00000350267	ENSP00000427687	bromodomain and PHD finger containing, 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity	WD repeat domain 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity)	0.900
HABP4	BRPF3	ENSP00000364398	ENSP00000350267	hyaluronan binding protein 4; May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription	bromodomain and PHD finger containing, 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity	0.900
HABP4	PLEK	ENSP00000364398	ENSP00000234313	hyaluronan binding protein 4; May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription	pleckstrin; Major protein kinase C substrate of platelets	0.900
HABP4	POTEI	ENSP00000364398	ENSP00000392718	hyaluronan binding protein 4; May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription	POTE ankyrin domain family, member I	0.900
HABP4	SOD1	ENSP00000364398	ENSP00000270142	hyaluronan binding protein 4; May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription	superoxide dismutase 1, soluble; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)	0.902
HABP4	TLN1	ENSP00000364398	ENSP00000316029	hyaluronan binding protein 4; May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription	talin 1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity)	0.900
HABP4	TTN	ENSP00000364398	ENSP00000343764	hyaluronan binding protein 4; May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription	titin	0.900
HABP4	TUBA4A	ENSP00000364398	ENSP00000248437	hyaluronan binding protein 4; May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription	tubulin, alpha 4a; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)	0.903
HABP4	VCL	ENSP00000364398	ENSP00000211998	hyaluronan binding protein 4; May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription	vinculin; Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion	0.900
HABP4	WDR1	ENSP00000364398	ENSP00000427687	hyaluronan binding protein 4; May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription	WD repeat domain 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity)	0.900
PHLPP2	PLEK	ENSP00000348611	ENSP00000234313	PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...]	pleckstrin; Major protein kinase C substrate of platelets	0.414
PHLPP2	POTEI	ENSP00000348611	ENSP00000392718	PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...]	POTE ankyrin domain family, member I	0.890

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