| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AQP1 | SLC4A10 | ENSP00000311165 | ENSP00000393066 | aquaporin 1 (Colton blood group); Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient | solute carrier family 4, sodium bicarbonate transporter, member 10; Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity) | 0.641 |
| AQP1 | SLC9A1 | ENSP00000311165 | ENSP00000263980 | aquaporin 1 (Colton blood group); Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction | 0.583 |
| CEP72 | SLC4A10 | ENSP00000264935 | ENSP00000393066 | centrosomal protein 72kDa; Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ/PLK1S1, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) | solute carrier family 4, sodium bicarbonate transporter, member 10; Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity) | 0.567 |
| SLC26A1 | SLC4A10 | ENSP00000354721 | ENSP00000393066 | solute carrier family 26 (sulfate transporter), member 1; High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate | solute carrier family 4, sodium bicarbonate transporter, member 10; Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity) | 0.536 |
| SLC26A3 | SLC4A10 | ENSP00000345873 | ENSP00000393066 | solute carrier family 26, member 3; Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon, participating in fluid homeostasis | solute carrier family 4, sodium bicarbonate transporter, member 10; Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity) | 0.509 |
| SLC26A3 | SLC9A1 | ENSP00000345873 | ENSP00000263980 | solute carrier family 26, member 3; Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon, participating in fluid homeostasis | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction | 0.527 |
| SLC26A3 | SLC9A3R1 | ENSP00000345873 | ENSP00000262613 | solute carrier family 26, member 3; Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon, participating in fluid homeostasis | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli ( [...] | 0.737 |
| SLC26A4 | SLC4A10 | ENSP00000265715 | ENSP00000393066 | solute carrier family 26, member 4; Sodium-independent transporter of chloride and iodide | solute carrier family 4, sodium bicarbonate transporter, member 10; Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity) | 0.582 |
| SLC26A6 | SLC4A10 | ENSP00000378920 | ENSP00000393066 | solute carrier family 26, member 6; Does not seem to be involved in anion transport | solute carrier family 4, sodium bicarbonate transporter, member 10; Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity) | 0.509 |
| SLC26A6 | SLC9A1 | ENSP00000378920 | ENSP00000263980 | solute carrier family 26, member 6; Does not seem to be involved in anion transport | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction | 0.587 |
| SLC26A6 | SLC9A3R1 | ENSP00000378920 | ENSP00000262613 | solute carrier family 26, member 6; Does not seem to be involved in anion transport | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli ( [...] | 0.488 |
| SLC26A7 | SLC4A10 | ENSP00000309504 | ENSP00000393066 | solute carrier family 26, member 7; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion | solute carrier family 4, sodium bicarbonate transporter, member 10; Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity) | 0.605 |
| SLC26A9 | SLC4A10 | ENSP00000341682 | ENSP00000393066 | solute carrier family 26, member 9; DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate | solute carrier family 4, sodium bicarbonate transporter, member 10; Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity) | 0.619 |
| SLC4A10 | AQP1 | ENSP00000393066 | ENSP00000311165 | solute carrier family 4, sodium bicarbonate transporter, member 10; Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity) | aquaporin 1 (Colton blood group); Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient | 0.641 |
| SLC4A10 | CEP72 | ENSP00000393066 | ENSP00000264935 | solute carrier family 4, sodium bicarbonate transporter, member 10; Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity) | centrosomal protein 72kDa; Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ/PLK1S1, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) | 0.567 |
| SLC4A10 | SLC26A1 | ENSP00000393066 | ENSP00000354721 | solute carrier family 4, sodium bicarbonate transporter, member 10; Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity) | solute carrier family 26 (sulfate transporter), member 1; High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate | 0.536 |
| SLC4A10 | SLC26A3 | ENSP00000393066 | ENSP00000345873 | solute carrier family 4, sodium bicarbonate transporter, member 10; Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity) | solute carrier family 26, member 3; Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon, participating in fluid homeostasis | 0.509 |
| SLC4A10 | SLC26A4 | ENSP00000393066 | ENSP00000265715 | solute carrier family 4, sodium bicarbonate transporter, member 10; Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity) | solute carrier family 26, member 4; Sodium-independent transporter of chloride and iodide | 0.582 |
| SLC4A10 | SLC26A6 | ENSP00000393066 | ENSP00000378920 | solute carrier family 4, sodium bicarbonate transporter, member 10; Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity) | solute carrier family 26, member 6; Does not seem to be involved in anion transport | 0.509 |
| SLC4A10 | SLC26A7 | ENSP00000393066 | ENSP00000309504 | solute carrier family 4, sodium bicarbonate transporter, member 10; Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity) | solute carrier family 26, member 7; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion | 0.605 |
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