HES4 protein (Homo sapiens) - STRING network view

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HES4

hairy and enhancer of split 4 (Drosophila) (247 aa)

Predicted Functional Partners:

NOTCH1

0.822

NOTCH3

0.800

NOTCH2

0.758

WNT2B

0.722

WNT2

0.722

NEUROG1

0.707

TBX19

0.688

T

0.688

CHRD

0.688

TLE2

0.662

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHRD	HES4	ENSP00000204604	ENSP00000393198	chordin	hairy and enhancer of split 4 (Drosophila)	0.688
CHRD	NOTCH1	ENSP00000204604	ENSP00000277541	chordin	notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...]	0.412
CHRD	T	ENSP00000204604	ENSP00000296946	chordin	T, brachyury homolog (mouse); Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site	0.493
CHRD	TBX19	ENSP00000204604	ENSP00000356795	chordin	T-box 19; Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters	0.530
CHRD	WNT2	ENSP00000204604	ENSP00000265441	chordin	wingless-type MMTV integration site family member 2; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters	0.465
CHRD	WNT2B	ENSP00000204604	ENSP00000358698	chordin	wingless-type MMTV integration site family, member 2B; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May be involved in normal development or differentiation as well as in carcinogenesis	0.459
HES4	CHRD	ENSP00000393198	ENSP00000204604	hairy and enhancer of split 4 (Drosophila)	chordin	0.688
HES4	NEUROG1	ENSP00000393198	ENSP00000317580	hairy and enhancer of split 4 (Drosophila)	neurogenin 1; Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity)	0.707
HES4	NOTCH1	ENSP00000393198	ENSP00000277541	hairy and enhancer of split 4 (Drosophila)	notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...]	0.822
HES4	NOTCH2	ENSP00000393198	ENSP00000256646	hairy and enhancer of split 4 (Drosophila)	notch 2	0.758
HES4	NOTCH3	ENSP00000393198	ENSP00000263388	hairy and enhancer of split 4 (Drosophila)	notch 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity)	0.800
HES4	T	ENSP00000393198	ENSP00000296946	hairy and enhancer of split 4 (Drosophila)	T, brachyury homolog (mouse); Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site	0.688
HES4	TBX19	ENSP00000393198	ENSP00000356795	hairy and enhancer of split 4 (Drosophila)	T-box 19; Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters	0.688
HES4	TLE2	ENSP00000393198	ENSP00000262953	hairy and enhancer of split 4 (Drosophila)	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity)	0.662
HES4	WNT2	ENSP00000393198	ENSP00000265441	hairy and enhancer of split 4 (Drosophila)	wingless-type MMTV integration site family member 2; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters	0.722
HES4	WNT2B	ENSP00000393198	ENSP00000358698	hairy and enhancer of split 4 (Drosophila)	wingless-type MMTV integration site family, member 2B; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May be involved in normal development or differentiation as well as in carcinogenesis	0.722
NEUROG1	HES4	ENSP00000317580	ENSP00000393198	neurogenin 1; Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity)	hairy and enhancer of split 4 (Drosophila)	0.707
NEUROG1	NOTCH1	ENSP00000317580	ENSP00000277541	neurogenin 1; Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity)	notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...]	0.508
NOTCH1	CHRD	ENSP00000277541	ENSP00000204604	notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...]	chordin	0.412
NOTCH1	HES4	ENSP00000277541	ENSP00000393198	notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...]	hairy and enhancer of split 4 (Drosophila)	0.822

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