node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSF2RA | CSF2RB | ENSP00000394227 | ENSP00000384053 | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor | 0.998 |
CSF2RA | IFNA13 | ENSP00000394227 | ENSP00000394494 | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | interferon, alpha 13 | 0.800 |
CSF2RA | JAK2 | ENSP00000394227 | ENSP00000371067 | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | Janus kinase 2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylate [...] | 0.939 |
CSF2RA | JAK3 | ENSP00000394227 | ENSP00000391676 | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | Janus kinase 3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor [...] | 0.834 |
CSF2RB | CSF2RA | ENSP00000384053 | ENSP00000394227 | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | 0.998 |
CSF2RB | IFNA13 | ENSP00000384053 | ENSP00000394494 | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor | interferon, alpha 13 | 0.800 |
CSF2RB | IL5RA | ENSP00000384053 | ENSP00000256452 | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor | interleukin 5 receptor, alpha; This is the receptor for interleukin-5. The alpha chain binds to IL5 | 0.992 |
CSF2RB | JAK2 | ENSP00000384053 | ENSP00000371067 | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor | Janus kinase 2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylate [...] | 0.999 |
CSF2RB | JAK3 | ENSP00000384053 | ENSP00000391676 | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor | Janus kinase 3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor [...] | 0.918 |
ENSG00000249624 | IFNA13 | ENSP00000388223 | ENSP00000394494 | Uncharacterized protein | interferon, alpha 13 | 0.800 |
ENSG00000249624 | IL22RA1 | ENSP00000388223 | ENSP00000270800 | Uncharacterized protein | interleukin 22 receptor, alpha 1; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation | 0.800 |
ENSG00000249624 | JAK2 | ENSP00000388223 | ENSP00000371067 | Uncharacterized protein | Janus kinase 2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylate [...] | 0.800 |
ENSG00000249624 | JAK3 | ENSP00000388223 | ENSP00000391676 | Uncharacterized protein | Janus kinase 3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor [...] | 0.800 |
ENSG00000258728 | IFNA13 | ENSP00000451792 | ENSP00000394494 | Uncharacterized protein | interferon, alpha 13 | 0.800 |
ENSG00000258728 | JAK2 | ENSP00000451792 | ENSP00000371067 | Uncharacterized protein | Janus kinase 2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylate [...] | 0.800 |
ENSG00000258728 | JAK3 | ENSP00000451792 | ENSP00000391676 | Uncharacterized protein | Janus kinase 3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor [...] | 0.800 |
IFNA13 | CSF2RA | ENSP00000394494 | ENSP00000394227 | interferon, alpha 13 | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | 0.800 |
IFNA13 | CSF2RB | ENSP00000394494 | ENSP00000384053 | interferon, alpha 13 | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor | 0.800 |
IFNA13 | ENSG00000249624 | ENSP00000394494 | ENSP00000388223 | interferon, alpha 13 | Uncharacterized protein | 0.800 |
IFNA13 | ENSG00000258728 | ENSP00000394494 | ENSP00000451792 | interferon, alpha 13 | Uncharacterized protein | 0.800 |