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STRINGSTRING
IL12RB1 IL12RB1 ENSG00000258728 ENSG00000258728 IL22RA1 IL22RA1 JAK3 JAK3 IFNA13 IFNA13 ENSG00000249624 ENSG00000249624 CSF2RA CSF2RA JAK2 JAK2 IL5RA IL5RA CSF2RB CSF2RB PRLR PRLR
"IFNA13" - interferon, alpha 13 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
IFNA13interferon, alpha 13 (190 aa)    
Predicted Functional Partners:
IL5RA
interleukin 5 receptor, alpha; This is the receptor for interleukin-5. The alpha chain binds to IL5 (420 aa)
          score_image score_image   0.802
IL22RA1
interleukin 22 receptor, alpha 1; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation (574 aa)
          score_image score_image   0.801
ENSG00000258728
Uncharacterized protein (280 aa)
          score_image     0.800
IL12RB1
interleukin 12 receptor, beta 1; Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade (662 aa)
          score_image     0.800
CSF2RA
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) (434 aa)
          score_image     0.800
JAK3
Janus kinase 3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor [...] (1124 aa)
          score_image     0.800
ENSG00000249624
Uncharacterized protein (333 aa)
          score_image     0.800
CSF2RB
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor (897 aa)
          score_image     0.800
PRLR
prolactin receptor (622 aa)
          score_image     0.800
JAK2
Janus kinase 2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylate [...] (1132 aa)
          score_image     0.800
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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