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STRINGSTRING
PRR25 PRR25 PRR21 PRR21 DNAJC24 DNAJC24 NRL NRL PRR12 PRR12 RNH1 RNH1 BCL2L12 BCL2L12 UBC UBC USP7 USP7 SCAF1 SCAF1 RAD51 RAD51
"PRR12" - proline rich 12 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRR12proline rich 12 (2036 aa)    
Predicted Functional Partners:
PRR21
proline rich 21 (389 aa)
            score_image   0.819
RNH1
ribonuclease/angiogenin inhibitor 1; Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis (461 aa)
        score_image   score_image   0.664
USP7
ubiquitin specific peptidase 7 (herpes virus-associated); Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53- dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen pero [...] (1102 aa)
        score_image       0.644
NRL
neural retina leucine zipper; Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B (By similarity) (237 aa)
            score_image   0.563
PRR25
proline rich 25 (402 aa)
            score_image   0.561
SCAF1
SR-related CTD-associated factor 1; May function in pre-mRNA splicing (By similarity) (1312 aa)
            score_image   0.517
BCL2L12
BCL2-like 12 (proline rich) (334 aa)
            score_image   0.513
UBC
ubiquitin C (685 aa)
        score_image       0.483
RAD51
RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 (340 aa)
            score_image   0.479
DNAJC24
DnaJ (Hsp40) homolog, subfamily C, member 24; Stimulates the ATPase activity of several Hsp70-type chaperones (By similarity) (149 aa)
            score_image   0.472
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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