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STRINGSTRING
GRK4 GRK4 GRK6 GRK6 OPRM1 OPRM1 OPRD1 OPRD1 GNAO1 GNAO1 CNR2 CNR2 PDYN PDYN CNR1 CNR1 GNAI1 GNAI1 PENK PENK POMC POMC
"OPRM1" - opioid receptor, mu 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
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cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
OPRM1opioid receptor, mu 1 (493 aa)    
Predicted Functional Partners:
OPRD1
opioid receptor, delta 1; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins (372 aa)
        score_image score_image score_image score_image 0.981
PENK
proenkephalin; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum (267 aa)
        score_image score_image score_image   0.973
CNR2
cannabinoid receptor 2 (macrophage); Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis (360 aa)
          score_image score_image   0.967
PDYN
prodynorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity) (254 aa)
          score_image score_image   0.964
GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 (354 aa)
        score_image score_image score_image   0.962
GRK4
G protein-coupled receptor kinase 4 (578 aa)
          score_image score_image   0.959
GRK6
G protein-coupled receptor kinase 6; Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor- LRP6 during Wnt signaling (in vitro) (589 aa)
          score_image score_image   0.958
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (354 aa)
        score_image score_image score_image   0.957
POMC
proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol (267 aa)
          score_image score_image   0.949
CNR1
cannabinoid receptor 1 (brain) (472 aa)
          score_image score_image   0.948
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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