node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNR1 | CNR2 | ENSP00000358511 | ENSP00000363596 | cannabinoid receptor 1 (brain) | cannabinoid receptor 2 (macrophage); Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis | 0.907 |
CNR1 | GNAI1 | ENSP00000358511 | ENSP00000343027 | cannabinoid receptor 1 (brain) | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.956 |
CNR1 | GNAO1 | ENSP00000358511 | ENSP00000262493 | cannabinoid receptor 1 (brain) | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 | 0.831 |
CNR1 | OPRD1 | ENSP00000358511 | ENSP00000234961 | cannabinoid receptor 1 (brain) | opioid receptor, delta 1; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins | 0.922 |
CNR1 | OPRM1 | ENSP00000358511 | ENSP00000394624 | cannabinoid receptor 1 (brain) | opioid receptor, mu 1 | 0.948 |
CNR1 | PDYN | ENSP00000358511 | ENSP00000217305 | cannabinoid receptor 1 (brain) | prodynorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity) | 0.948 |
CNR1 | PENK | ENSP00000358511 | ENSP00000324248 | cannabinoid receptor 1 (brain) | proenkephalin; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum | 0.948 |
CNR1 | POMC | ENSP00000358511 | ENSP00000264708 | cannabinoid receptor 1 (brain) | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | 0.954 |
CNR2 | CNR1 | ENSP00000363596 | ENSP00000358511 | cannabinoid receptor 2 (macrophage); Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis | cannabinoid receptor 1 (brain) | 0.907 |
CNR2 | GNAI1 | ENSP00000363596 | ENSP00000343027 | cannabinoid receptor 2 (macrophage); Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.903 |
CNR2 | OPRD1 | ENSP00000363596 | ENSP00000234961 | cannabinoid receptor 2 (macrophage); Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis | opioid receptor, delta 1; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins | 0.919 |
CNR2 | OPRM1 | ENSP00000363596 | ENSP00000394624 | cannabinoid receptor 2 (macrophage); Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis | opioid receptor, mu 1 | 0.967 |
CNR2 | PDYN | ENSP00000363596 | ENSP00000217305 | cannabinoid receptor 2 (macrophage); Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis | prodynorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity) | 0.906 |
CNR2 | PENK | ENSP00000363596 | ENSP00000324248 | cannabinoid receptor 2 (macrophage); Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis | proenkephalin; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum | 0.928 |
CNR2 | POMC | ENSP00000363596 | ENSP00000264708 | cannabinoid receptor 2 (macrophage); Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | 0.916 |
GNAI1 | CNR1 | ENSP00000343027 | ENSP00000358511 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | cannabinoid receptor 1 (brain) | 0.956 |
GNAI1 | CNR2 | ENSP00000343027 | ENSP00000363596 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | cannabinoid receptor 2 (macrophage); Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis | 0.903 |
GNAI1 | GNAO1 | ENSP00000343027 | ENSP00000262493 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 | 0.955 |
GNAI1 | OPRD1 | ENSP00000343027 | ENSP00000234961 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | opioid receptor, delta 1; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins | 0.958 |
GNAI1 | OPRM1 | ENSP00000343027 | ENSP00000394624 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | opioid receptor, mu 1 | 0.957 |