PPT1 protein (Homo sapiens) - STRING network view

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PPT1

palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons (306 aa)

Predicted Functional Partners:

MECR

0.904

ENSG00000261832

0.901

CLN3

0.900

TPP1

0.836

CLN6

0.820

ACSL1

0.812

ACSBG1

0.812

ACSL5

0.811

ACSBG2

0.808

ACSL4

0.806

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACSBG1	PPT1	ENSP00000258873	ENSP00000394863	acyl-CoA synthetase bubblegum family member 1; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids	palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons	0.812
ACSBG2	PPT1	ENSP00000252669	ENSP00000394863	acyl-CoA synthetase bubblegum family member 2; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis	palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons	0.808
ACSL1	PPT1	ENSP00000281455	ENSP00000394863	acyl-CoA synthetase long-chain family member 1; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate	palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons	0.812
ACSL4	PPT1	ENSP00000339787	ENSP00000394863	acyl-CoA synthetase long-chain family member 4; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates	palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons	0.806
ACSL5	PPT1	ENSP00000348429	ENSP00000394863	acyl-CoA synthetase long-chain family member 5; Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine [...]	palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons	0.811
CLN3	CLN6	ENSP00000353073	ENSP00000249806	ceroid-lipofuscinosis, neuronal 3	ceroid-lipofuscinosis, neuronal 6, late infantile, variant	0.888
CLN3	PPT1	ENSP00000353073	ENSP00000394863	ceroid-lipofuscinosis, neuronal 3	palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons	0.900
CLN3	TPP1	ENSP00000353073	ENSP00000299427	ceroid-lipofuscinosis, neuronal 3	tripeptidyl peptidase I; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity)	0.925
CLN6	CLN3	ENSP00000249806	ENSP00000353073	ceroid-lipofuscinosis, neuronal 6, late infantile, variant	ceroid-lipofuscinosis, neuronal 3	0.888
CLN6	ENSG00000261832	ENSP00000249806	ENSP00000454253	ceroid-lipofuscinosis, neuronal 6, late infantile, variant	Battenin; CLN3 protein; Uncharacterized protein	0.917
CLN6	PPT1	ENSP00000249806	ENSP00000394863	ceroid-lipofuscinosis, neuronal 6, late infantile, variant	palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons	0.820
CLN6	TPP1	ENSP00000249806	ENSP00000299427	ceroid-lipofuscinosis, neuronal 6, late infantile, variant	tripeptidyl peptidase I; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity)	0.836
ENSG00000261832	CLN6	ENSP00000454253	ENSP00000249806	Battenin; CLN3 protein; Uncharacterized protein	ceroid-lipofuscinosis, neuronal 6, late infantile, variant	0.917
ENSG00000261832	PPT1	ENSP00000454253	ENSP00000394863	Battenin; CLN3 protein; Uncharacterized protein	palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons	0.901
ENSG00000261832	TPP1	ENSP00000454253	ENSP00000299427	Battenin; CLN3 protein; Uncharacterized protein	tripeptidyl peptidase I; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity)	0.930
MECR	PPT1	ENSP00000263702	ENSP00000394863	mitochondrial trans-2-enoyl-CoA reductase; Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial synthesis of fatty acids	palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons	0.904
PPT1	ACSBG1	ENSP00000394863	ENSP00000258873	palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons	acyl-CoA synthetase bubblegum family member 1; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids	0.812
PPT1	ACSBG2	ENSP00000394863	ENSP00000252669	palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons	acyl-CoA synthetase bubblegum family member 2; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis	0.808
PPT1	ACSL1	ENSP00000394863	ENSP00000281455	palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons	acyl-CoA synthetase long-chain family member 1; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate	0.812
PPT1	ACSL4	ENSP00000394863	ENSP00000339787	palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons	acyl-CoA synthetase long-chain family member 4; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates	0.806

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