| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DYNLT3 | SYTL5 | ENSP00000367841 | ENSP00000395220 | dynein, light chain, Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity) | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | 0.665 |
| E2F3 | SYTL5 | ENSP00000262904 | ENSP00000395220 | E2F transcription factor 3; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | 0.575 |
| PRSS37 | SYTL5 | ENSP00000297767 | ENSP00000395220 | protease, serine, 37 | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | 0.535 |
| RAB27A | SAC3D1 | ENSP00000337761 | ENSP00000381824 | RAB27A, member RAS oncogene family; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse | SAC3 domain containing 1; Involved in centrosome duplication and mitotic progression (By similarity) | 0.538 |
| RAB27A | SYTL5 | ENSP00000337761 | ENSP00000395220 | RAB27A, member RAS oncogene family; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | 0.937 |
| RAB27A | UNC13D | ENSP00000337761 | ENSP00000207549 | RAB27A, member RAS oncogene family; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse | unc-13 homolog D (C. elegans); Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells | 0.983 |
| RAB27B | SYTL5 | ENSP00000262094 | ENSP00000395220 | RAB27B, member RAS oncogene family; May be involved in targeting uroplakins to urothelial apical membranes (By similarity) | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | 0.812 |
| RAB27B | UNC13D | ENSP00000262094 | ENSP00000207549 | RAB27B, member RAS oncogene family; May be involved in targeting uroplakins to urothelial apical membranes (By similarity) | unc-13 homolog D (C. elegans); Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells | 0.870 |
| RAB3A | SAC3D1 | ENSP00000222256 | ENSP00000381824 | RAB3A, member RAS oncogene family; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal | SAC3 domain containing 1; Involved in centrosome duplication and mitotic progression (By similarity) | 0.427 |
| RAB3A | SYTL5 | ENSP00000222256 | ENSP00000395220 | RAB3A, member RAS oncogene family; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | 0.754 |
| RAB6A | SYTL5 | ENSP00000311449 | ENSP00000395220 | RAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | 0.663 |
| SAC3D1 | RAB27A | ENSP00000381824 | ENSP00000337761 | SAC3 domain containing 1; Involved in centrosome duplication and mitotic progression (By similarity) | RAB27A, member RAS oncogene family; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse | 0.538 |
| SAC3D1 | RAB3A | ENSP00000381824 | ENSP00000222256 | SAC3 domain containing 1; Involved in centrosome duplication and mitotic progression (By similarity) | RAB3A, member RAS oncogene family; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal | 0.427 |
| SAC3D1 | SYTL5 | ENSP00000381824 | ENSP00000395220 | SAC3 domain containing 1; Involved in centrosome duplication and mitotic progression (By similarity) | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | 0.604 |
| SYTL5 | DYNLT3 | ENSP00000395220 | ENSP00000367841 | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | dynein, light chain, Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity) | 0.665 |
| SYTL5 | E2F3 | ENSP00000395220 | ENSP00000262904 | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | E2F transcription factor 3; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner | 0.575 |
| SYTL5 | PRSS37 | ENSP00000395220 | ENSP00000297767 | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | protease, serine, 37 | 0.535 |
| SYTL5 | RAB27A | ENSP00000395220 | ENSP00000337761 | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | RAB27A, member RAS oncogene family; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse | 0.937 |
| SYTL5 | RAB27B | ENSP00000395220 | ENSP00000262094 | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | RAB27B, member RAS oncogene family; May be involved in targeting uroplakins to urothelial apical membranes (By similarity) | 0.812 |
| SYTL5 | RAB3A | ENSP00000395220 | ENSP00000222256 | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | RAB3A, member RAS oncogene family; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal | 0.754 |
Share
