FAM54A protein (Homo sapiens) - STRING network view

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FAM54A

family with sequence similarity 54, member A; May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity) (385 aa)

Predicted Functional Partners:

UBC

0.620

ISM2

0.582

C1orf158

0.582

IL22RA2

0.580

CCDC61

0.502

NHSL1

0.499

BCLAF1

0.497

DICER1

0.481

VTA1

0.472

TAAR6

0.459

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCLAF1	FAM54A	ENSP00000435210	ENSP00000395232	BCL2-associated transcription factor 1; Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3’end of the CCND1 gene and its mRNA	family with sequence similarity 54, member A; May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity)	0.497
BCLAF1	UBC	ENSP00000435210	ENSP00000344818	BCL2-associated transcription factor 1; Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3’end of the CCND1 gene and its mRNA	ubiquitin C	0.854
C1orf158	CCDC61	ENSP00000288048	ENSP00000263284	chromosome 1 open reading frame 158	coiled-coil domain containing 61	0.592
C1orf158	FAM54A	ENSP00000288048	ENSP00000395232	chromosome 1 open reading frame 158	family with sequence similarity 54, member A; May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity)	0.582
C1orf158	ISM2	ENSP00000288048	ENSP00000341490	chromosome 1 open reading frame 158	isthmin 2 homolog (zebrafish)	0.593
CCDC61	C1orf158	ENSP00000263284	ENSP00000288048	coiled-coil domain containing 61	chromosome 1 open reading frame 158	0.592
CCDC61	FAM54A	ENSP00000263284	ENSP00000395232	coiled-coil domain containing 61	family with sequence similarity 54, member A; May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity)	0.502
CCDC61	ISM2	ENSP00000263284	ENSP00000341490	coiled-coil domain containing 61	isthmin 2 homolog (zebrafish)	0.592
DICER1	FAM54A	ENSP00000343745	ENSP00000395232	dicer 1, ribonuclease type III; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre- miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering [...]	family with sequence similarity 54, member A; May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity)	0.481
DICER1	UBC	ENSP00000343745	ENSP00000344818	dicer 1, ribonuclease type III; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre- miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering [...]	ubiquitin C	0.697
FAM54A	BCLAF1	ENSP00000395232	ENSP00000435210	family with sequence similarity 54, member A; May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity)	BCL2-associated transcription factor 1; Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3’end of the CCND1 gene and its mRNA	0.497
FAM54A	C1orf158	ENSP00000395232	ENSP00000288048	family with sequence similarity 54, member A; May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity)	chromosome 1 open reading frame 158	0.582
FAM54A	CCDC61	ENSP00000395232	ENSP00000263284	family with sequence similarity 54, member A; May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity)	coiled-coil domain containing 61	0.502
FAM54A	DICER1	ENSP00000395232	ENSP00000343745	family with sequence similarity 54, member A; May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity)	dicer 1, ribonuclease type III; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre- miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering [...]	0.481
FAM54A	IL22RA2	ENSP00000395232	ENSP00000296980	family with sequence similarity 54, member A; May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity)	interleukin 22 receptor, alpha 2; Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses	0.580
FAM54A	ISM2	ENSP00000395232	ENSP00000341490	family with sequence similarity 54, member A; May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity)	isthmin 2 homolog (zebrafish)	0.582
FAM54A	NHSL1	ENSP00000395232	ENSP00000394546	family with sequence similarity 54, member A; May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity)	NHS-like 1	0.499
FAM54A	TAAR6	ENSP00000395232	ENSP00000275198	family with sequence similarity 54, member A; May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity)	trace amine associated receptor 6; Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood	0.459
FAM54A	UBC	ENSP00000395232	ENSP00000344818	family with sequence similarity 54, member A; May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity)	ubiquitin C	0.620
FAM54A	VTA1	ENSP00000395232	ENSP00000356602	family with sequence similarity 54, member A; May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity)	Vps20-associated 1 homolog (S. cerevisiae); Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding	0.472

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