node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD46 | CCDC14 | ENSP00000335287 | ENSP00000395706 | ankyrin repeat domain 46 | coiled-coil domain containing 14 | 0.564 |
ANKRD46 | UBC | ENSP00000335287 | ENSP00000344818 | ankyrin repeat domain 46 | ubiquitin C | 0.863 |
ANXA10 | CCDC14 | ENSP00000352248 | ENSP00000395706 | annexin A10 | coiled-coil domain containing 14 | 0.604 |
ANXA10 | GEN1 | ENSP00000352248 | ENSP00000318977 | annexin A10 | Gen endonuclease homolog 1 (Drosophila); Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation | 0.499 |
ANXA10 | MSGN1 | ENSP00000352248 | ENSP00000281047 | annexin A10 | mesogenin 1; Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By similarity) | 0.554 |
ANXA10 | SPOCK3 | ENSP00000352248 | ENSP00000349677 | annexin A10 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 | 0.531 |
ANXA10 | VSNL1 | ENSP00000352248 | ENSP00000295156 | annexin A10 | visinin-like 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner (By similarity) | 0.510 |
CCDC14 | ANKRD46 | ENSP00000395706 | ENSP00000335287 | coiled-coil domain containing 14 | ankyrin repeat domain 46 | 0.564 |
CCDC14 | ANXA10 | ENSP00000395706 | ENSP00000352248 | coiled-coil domain containing 14 | annexin A10 | 0.604 |
CCDC14 | GEN1 | ENSP00000395706 | ENSP00000318977 | coiled-coil domain containing 14 | Gen endonuclease homolog 1 (Drosophila); Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation | 0.531 |
CCDC14 | MSGN1 | ENSP00000395706 | ENSP00000281047 | coiled-coil domain containing 14 | mesogenin 1; Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By similarity) | 0.603 |
CCDC14 | RNF31 | ENSP00000395706 | ENSP00000315112 | coiled-coil domain containing 14 | ring finger protein 31; E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear (’M-1’-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF- induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) followi [...] | 0.545 |
CCDC14 | SPOCK3 | ENSP00000395706 | ENSP00000349677 | coiled-coil domain containing 14 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 | 0.565 |
CCDC14 | STYX | ENSP00000395706 | ENSP00000346599 | coiled-coil domain containing 14 | serine/threonine/tyrosine interacting protein; Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase. The binding pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. Seems to play a role in spermiogenesis (By similarity) | 0.547 |
CCDC14 | UBC | ENSP00000395706 | ENSP00000344818 | coiled-coil domain containing 14 | ubiquitin C | 0.854 |
CCDC14 | UCHL1 | ENSP00000395706 | ENSP00000284440 | coiled-coil domain containing 14 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity | 0.740 |
CCDC14 | VSNL1 | ENSP00000395706 | ENSP00000295156 | coiled-coil domain containing 14 | visinin-like 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner (By similarity) | 0.574 |
GEN1 | ANXA10 | ENSP00000318977 | ENSP00000352248 | Gen endonuclease homolog 1 (Drosophila); Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation | annexin A10 | 0.499 |
GEN1 | CCDC14 | ENSP00000318977 | ENSP00000395706 | Gen endonuclease homolog 1 (Drosophila); Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation | coiled-coil domain containing 14 | 0.531 |
GEN1 | MSGN1 | ENSP00000318977 | ENSP00000281047 | Gen endonuclease homolog 1 (Drosophila); Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation | mesogenin 1; Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By similarity) | 0.422 |