node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD55 | SLC12A4 | ENSP00000316333 | ENSP00000395983 | CD55 molecule, decay accelerating factor for complement (Cromer blood group); This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade | solute carrier family 12 (potassium/chloride transporters), member 4 | 0.644 |
ILF3 | SLC12A4 | ENSP00000404121 | ENSP00000395983 | interleukin enhancer binding factor 3, 90kDa | solute carrier family 12 (potassium/chloride transporters), member 4 | 0.644 |
ILF3 | UBC | ENSP00000404121 | ENSP00000344818 | interleukin enhancer binding factor 3, 90kDa | ubiquitin C | 0.969 |
PSKH1 | PSMB10 | ENSP00000291041 | ENSP00000351314 | protein serine kinase H1; May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing | proteasome (prosome, macropain) subunit, beta type, 10; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides | 0.751 |
PSKH1 | SLC12A4 | ENSP00000291041 | ENSP00000395983 | protein serine kinase H1; May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing | solute carrier family 12 (potassium/chloride transporters), member 4 | 0.757 |
PSMB10 | PSKH1 | ENSP00000351314 | ENSP00000291041 | proteasome (prosome, macropain) subunit, beta type, 10; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides | protein serine kinase H1; May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing | 0.751 |
PSMB10 | SLC12A4 | ENSP00000351314 | ENSP00000395983 | proteasome (prosome, macropain) subunit, beta type, 10; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides | solute carrier family 12 (potassium/chloride transporters), member 4 | 0.661 |
PSMB10 | UBC | ENSP00000351314 | ENSP00000344818 | proteasome (prosome, macropain) subunit, beta type, 10; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides | ubiquitin C | 0.994 |
SLC12A4 | CD55 | ENSP00000395983 | ENSP00000316333 | solute carrier family 12 (potassium/chloride transporters), member 4 | CD55 molecule, decay accelerating factor for complement (Cromer blood group); This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade | 0.644 |
SLC12A4 | ILF3 | ENSP00000395983 | ENSP00000404121 | solute carrier family 12 (potassium/chloride transporters), member 4 | interleukin enhancer binding factor 3, 90kDa | 0.644 |
SLC12A4 | PSKH1 | ENSP00000395983 | ENSP00000291041 | solute carrier family 12 (potassium/chloride transporters), member 4 | protein serine kinase H1; May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing | 0.757 |
SLC12A4 | PSMB10 | ENSP00000395983 | ENSP00000351314 | solute carrier family 12 (potassium/chloride transporters), member 4 | proteasome (prosome, macropain) subunit, beta type, 10; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides | 0.661 |
SLC12A4 | STK39 | ENSP00000395983 | ENSP00000348278 | solute carrier family 12 (potassium/chloride transporters), member 4 | serine threonine kinase 39; May act as a mediator of stress-activated signals | 0.620 |
SLC12A4 | TMEM43 | ENSP00000395983 | ENSP00000303992 | solute carrier family 12 (potassium/chloride transporters), member 4 | transmembrane protein 43; May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity) | 0.644 |
SLC12A4 | UBC | ENSP00000395983 | ENSP00000344818 | solute carrier family 12 (potassium/chloride transporters), member 4 | ubiquitin C | 0.906 |
SLC12A4 | WNK1 | ENSP00000395983 | ENSP00000313059 | solute carrier family 12 (potassium/chloride transporters), member 4 | WNK lysine deficient protein kinase 1 | 0.627 |
SLC12A4 | WNK3 | ENSP00000395983 | ENSP00000346667 | solute carrier family 12 (potassium/chloride transporters), member 4 | WNK lysine deficient protein kinase 3; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway. Inhibits the activity of KCNJ1 by decreasing its expression at the c [...] | 0.740 |
SLC12A4 | WNK4 | ENSP00000395983 | ENSP00000246914 | solute carrier family 12 (potassium/chloride transporters), member 4 | WNK lysine deficient protein kinase 4; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-i [...] | 0.657 |
STK39 | SLC12A4 | ENSP00000348278 | ENSP00000395983 | serine threonine kinase 39; May act as a mediator of stress-activated signals | solute carrier family 12 (potassium/chloride transporters), member 4 | 0.620 |
STK39 | UBC | ENSP00000348278 | ENSP00000344818 | serine threonine kinase 39; May act as a mediator of stress-activated signals | ubiquitin C | 0.721 |