node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADARB2 | GPATCH4 | ENSP00000370713 | ENSP00000396441 | adenosine deaminase, RNA-specific, B2; Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA | G patch domain containing 4 | 0.481 |
FAM50A | GPATCH4 | ENSP00000377225 | ENSP00000396441 | family with sequence similarity 50, member A; May be a DNA-binding protein or transcriptional factor | G patch domain containing 4 | 0.702 |
FAM50A | IFT57 | ENSP00000377225 | ENSP00000264538 | family with sequence similarity 50, member A; May be a DNA-binding protein or transcriptional factor | intraflagellar transport 57 homolog (Chlamydomonas); Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5’-AAAGACATG-3’ present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear | 0.566 |
FAM50A | PSMC1 | ENSP00000377225 | ENSP00000261303 | family with sequence similarity 50, member A; May be a DNA-binding protein or transcriptional factor | proteasome (prosome, macropain) 26S subunit, ATPase, 1; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex | 0.587 |
FAM50A | SSSCA1 | ENSP00000377225 | ENSP00000312318 | family with sequence similarity 50, member A; May be a DNA-binding protein or transcriptional factor | Sjogren syndrome/scleroderma autoantigen 1; Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies | 0.789 |
FAM50B | GPATCH4 | ENSP00000369625 | ENSP00000396441 | family with sequence similarity 50, member B | G patch domain containing 4 | 0.587 |
FAM50B | IFT57 | ENSP00000369625 | ENSP00000264538 | family with sequence similarity 50, member B | intraflagellar transport 57 homolog (Chlamydomonas); Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5’-AAAGACATG-3’ present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear | 0.403 |
FAM50B | SSSCA1 | ENSP00000369625 | ENSP00000312318 | family with sequence similarity 50, member B | Sjogren syndrome/scleroderma autoantigen 1; Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies | 0.618 |
GPATCH4 | ADARB2 | ENSP00000396441 | ENSP00000370713 | G patch domain containing 4 | adenosine deaminase, RNA-specific, B2; Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA | 0.481 |
GPATCH4 | FAM50A | ENSP00000396441 | ENSP00000377225 | G patch domain containing 4 | family with sequence similarity 50, member A; May be a DNA-binding protein or transcriptional factor | 0.702 |
GPATCH4 | FAM50B | ENSP00000396441 | ENSP00000369625 | G patch domain containing 4 | family with sequence similarity 50, member B | 0.587 |
GPATCH4 | IFT57 | ENSP00000396441 | ENSP00000264538 | G patch domain containing 4 | intraflagellar transport 57 homolog (Chlamydomonas); Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5’-AAAGACATG-3’ present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear | 0.498 |
GPATCH4 | OR5L2 | ENSP00000396441 | ENSP00000367650 | G patch domain containing 4 | olfactory receptor, family 5, subfamily L, member 2; Odorant receptor (Potential) | 0.420 |
GPATCH4 | PSMC1 | ENSP00000396441 | ENSP00000261303 | G patch domain containing 4 | proteasome (prosome, macropain) 26S subunit, ATPase, 1; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex | 0.498 |
GPATCH4 | SSSCA1 | ENSP00000396441 | ENSP00000312318 | G patch domain containing 4 | Sjogren syndrome/scleroderma autoantigen 1; Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies | 0.637 |
GPATCH4 | TARBP2 | ENSP00000396441 | ENSP00000266987 | G patch domain containing 4 | TAR (HIV-1) RNA binding protein 2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre- miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interferin [...] | 0.481 |
GPATCH4 | ZNF292 | ENSP00000396441 | ENSP00000358590 | G patch domain containing 4 | zinc finger protein 292; May be involved in transcriptional regulation | 0.559 |
IFT57 | FAM50A | ENSP00000264538 | ENSP00000377225 | intraflagellar transport 57 homolog (Chlamydomonas); Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5’-AAAGACATG-3’ present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear | family with sequence similarity 50, member A; May be a DNA-binding protein or transcriptional factor | 0.566 |
IFT57 | FAM50B | ENSP00000264538 | ENSP00000369625 | intraflagellar transport 57 homolog (Chlamydomonas); Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5’-AAAGACATG-3’ present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear | family with sequence similarity 50, member B | 0.403 |
IFT57 | GPATCH4 | ENSP00000264538 | ENSP00000396441 | intraflagellar transport 57 homolog (Chlamydomonas); Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5’-AAAGACATG-3’ present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear | G patch domain containing 4 | 0.498 |