node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KDM1A | PRDM7 | ENSP00000383042 | ENSP00000396732 | lysine (K)-specific demethylase 1A | PR domain containing 7; Probable histone methyltransferase (By similarity) | 0.639 |
KDM1B | PRDM7 | ENSP00000297792 | ENSP00000396732 | lysine (K)-specific demethylase 1B; Histone demethylase that demethylates ’Lys-4’ of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated ’Lys-4’ of histone H3. Has no effect on tri- methylated ’Lys-4’, mono-, di- or tri-methylated ’Lys-9’, mono-, di- or tri-methylated ’Lys-27’, mono-, di- or tri-methylat [...] | PR domain containing 7; Probable histone methyltransferase (By similarity) | 0.638 |
MAOA | PRDM7 | ENSP00000340684 | ENSP00000396732 | monoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine | PR domain containing 7; Probable histone methyltransferase (By similarity) | 0.638 |
MAOB | PRDM7 | ENSP00000367309 | ENSP00000396732 | monoamine oxidase B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine | PR domain containing 7; Probable histone methyltransferase (By similarity) | 0.638 |
PRDM13 | PRDM7 | ENSP00000358217 | ENSP00000396732 | PR domain containing 13; May be involved in transcriptional regulation | PR domain containing 7; Probable histone methyltransferase (By similarity) | 0.598 |
PRDM7 | KDM1A | ENSP00000396732 | ENSP00000383042 | PR domain containing 7; Probable histone methyltransferase (By similarity) | lysine (K)-specific demethylase 1A | 0.639 |
PRDM7 | KDM1B | ENSP00000396732 | ENSP00000297792 | PR domain containing 7; Probable histone methyltransferase (By similarity) | lysine (K)-specific demethylase 1B; Histone demethylase that demethylates ’Lys-4’ of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated ’Lys-4’ of histone H3. Has no effect on tri- methylated ’Lys-4’, mono-, di- or tri-methylated ’Lys-9’, mono-, di- or tri-methylated ’Lys-27’, mono-, di- or tri-methylat [...] | 0.638 |
PRDM7 | MAOA | ENSP00000396732 | ENSP00000340684 | PR domain containing 7; Probable histone methyltransferase (By similarity) | monoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine | 0.638 |
PRDM7 | MAOB | ENSP00000396732 | ENSP00000367309 | PR domain containing 7; Probable histone methyltransferase (By similarity) | monoamine oxidase B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine | 0.638 |
PRDM7 | PRDM13 | ENSP00000396732 | ENSP00000358217 | PR domain containing 7; Probable histone methyltransferase (By similarity) | PR domain containing 13; May be involved in transcriptional regulation | 0.598 |
PRDM7 | UNC5A | ENSP00000396732 | ENSP00000332737 | PR domain containing 7; Probable histone methyltransferase (By similarity) | unc-5 homolog A (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand | 0.610 |
PRDM7 | UNC5B | ENSP00000396732 | ENSP00000334329 | PR domain containing 7; Probable histone methyltransferase (By similarity) | unc-5 homolog B (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity | 0.610 |
PRDM7 | UNC5C | ENSP00000396732 | ENSP00000406022 | PR domain containing 7; Probable histone methyltransferase (By similarity) | unc-5 homolog C (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) | 0.610 |
PRDM7 | UNC5CL | ENSP00000396732 | ENSP00000244565 | PR domain containing 7; Probable histone methyltransferase (By similarity) | unc-5 homolog C (C. elegans)-like; Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets | 0.610 |
PRDM7 | UNC5D | ENSP00000396732 | ENSP00000385143 | PR domain containing 7; Probable histone methyltransferase (By similarity) | unc-5 homolog D (C. elegans); Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) | 0.610 |
UNC5A | PRDM7 | ENSP00000332737 | ENSP00000396732 | unc-5 homolog A (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand | PR domain containing 7; Probable histone methyltransferase (By similarity) | 0.610 |
UNC5A | UNC5B | ENSP00000332737 | ENSP00000334329 | unc-5 homolog A (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand | unc-5 homolog B (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity | 0.904 |
UNC5A | UNC5C | ENSP00000332737 | ENSP00000406022 | unc-5 homolog A (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand | unc-5 homolog C (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) | 0.904 |
UNC5A | UNC5D | ENSP00000332737 | ENSP00000385143 | unc-5 homolog A (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand | unc-5 homolog D (C. elegans); Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) | 0.906 |
UNC5B | PRDM7 | ENSP00000334329 | ENSP00000396732 | unc-5 homolog B (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity | PR domain containing 7; Probable histone methyltransferase (By similarity) | 0.610 |