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UNC5D UNC5D UNC5C UNC5C UNC5B UNC5B UNC5A UNC5A MAOB MAOB KDM1A KDM1A PRDM7 PRDM7 MAOA MAOA PRDM13 PRDM13 KDM1B KDM1B UNC5CL UNC5CL
"PRDM7" - PR domain containing 7 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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second shell of interactors
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Predicted Interactions
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textmining
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protein homology
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[Homology]
Score
PRDM7PR domain containing 7; Probable histone methyltransferase (By similarity) (492 aa)    
Predicted Functional Partners:
KDM1A
lysine (K)-specific demethylase 1A (876 aa)
            score_image   0.639
MAOB
monoamine oxidase B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (520 aa)
            score_image   0.638
MAOA
monoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (527 aa)
            score_image   0.638
KDM1B
lysine (K)-specific demethylase 1B; Histone demethylase that demethylates ’Lys-4’ of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated ’Lys-4’ of histone H3. Has no effect on tri- methylated ’Lys-4’, mono-, di- or tri-methylated ’Lys-9’, mono-, di- or tri-methylated ’Lys-27’, mono-, di- or tri-methylat [...] (590 aa)
            score_image   0.638
UNC5C
unc-5 homolog C (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) (931 aa)
            score_image   0.610
UNC5D
unc-5 homolog D (C. elegans); Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) (953 aa)
            score_image   0.610
UNC5B
unc-5 homolog B (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (945 aa)
            score_image   0.610
UNC5A
unc-5 homolog A (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (842 aa)
            score_image   0.610
UNC5CL
unc-5 homolog C (C. elegans)-like; Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets (518 aa)
            score_image   0.610
PRDM13
PR domain containing 13; May be involved in transcriptional regulation (707 aa)
            score_image   0.598
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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