node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASK | DLG1 | ENSP00000367408 | ENSP00000345731 | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | discs, large homolog 1 (Drosophila) | 0.969 |
CASK | DLG4 | ENSP00000367408 | ENSP00000293813 | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | 0.706 |
CASK | GRIK2 | ENSP00000367408 | ENSP00000397026 | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | glutamate receptor, ionotropic, kainate 2 | 0.924 |
DLG1 | CASK | ENSP00000345731 | ENSP00000367408 | discs, large homolog 1 (Drosophila) | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.969 |
DLG1 | DLG3 | ENSP00000345731 | ENSP00000363480 | discs, large homolog 1 (Drosophila) | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | 0.955 |
DLG1 | DLG4 | ENSP00000345731 | ENSP00000293813 | discs, large homolog 1 (Drosophila) | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | 0.956 |
DLG1 | GRIA1 | ENSP00000345731 | ENSP00000285900 | discs, large homolog 1 (Drosophila) | glutamate receptor, ionotropic, AMPA 1; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a [...] | 0.997 |
DLG1 | GRIK1 | ENSP00000345731 | ENSP00000382791 | discs, large homolog 1 (Drosophila) | glutamate receptor, ionotropic, kainate 1; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus | 0.522 |
DLG1 | GRIK2 | ENSP00000345731 | ENSP00000397026 | discs, large homolog 1 (Drosophila) | glutamate receptor, ionotropic, kainate 2 | 0.983 |
DLG1 | GRIK5 | ENSP00000345731 | ENSP00000262895 | discs, large homolog 1 (Drosophila) | glutamate receptor, ionotropic, kainate 5; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L- glutamate >> AMPA >> NMDA = 1S,3R-ACPD | 0.440 |
DLG1 | PICK1 | ENSP00000345731 | ENSP00000349465 | discs, large homolog 1 (Drosophila) | protein interacting with PRKCA 1; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel | 0.770 |
DLG3 | DLG1 | ENSP00000363480 | ENSP00000345731 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | discs, large homolog 1 (Drosophila) | 0.955 |
DLG3 | DLG4 | ENSP00000363480 | ENSP00000293813 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | 0.956 |
DLG3 | GRIA1 | ENSP00000363480 | ENSP00000285900 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | glutamate receptor, ionotropic, AMPA 1; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a [...] | 0.847 |
DLG3 | GRIK1 | ENSP00000363480 | ENSP00000382791 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | glutamate receptor, ionotropic, kainate 1; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus | 0.709 |
DLG3 | GRIK2 | ENSP00000363480 | ENSP00000397026 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | glutamate receptor, ionotropic, kainate 2 | 0.949 |
DLG3 | GRIK5 | ENSP00000363480 | ENSP00000262895 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | glutamate receptor, ionotropic, kainate 5; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L- glutamate >> AMPA >> NMDA = 1S,3R-ACPD | 0.816 |
DLG3 | PICK1 | ENSP00000363480 | ENSP00000349465 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | protein interacting with PRKCA 1; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel | 0.679 |
DLG4 | CASK | ENSP00000293813 | ENSP00000367408 | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.706 |
DLG4 | DLG1 | ENSP00000293813 | ENSP00000345731 | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | discs, large homolog 1 (Drosophila) | 0.956 |