node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FOS | RLN3 | ENSP00000306245 | ENSP00000397415 | FBJ murine osteosarcoma viral oncogene homolog; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell p [...] | relaxin 3; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142) | 0.834 |
INSL3 | INSL4 | ENSP00000321724 | ENSP00000239316 | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | insulin-like 4 (placenta); May play an important role in trophoblast development and in the regulation of bone formation | 0.750 |
INSL3 | INSL5 | ENSP00000321724 | ENSP00000302724 | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | insulin-like 5; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor | 0.701 |
INSL3 | RLN1 | ENSP00000321724 | ENSP00000223862 | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | relaxin 1; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix | 0.758 |
INSL3 | RLN2 | ENSP00000321724 | ENSP00000371040 | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | relaxin 2; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix | 0.635 |
INSL3 | RLN3 | ENSP00000321724 | ENSP00000397415 | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | relaxin 3; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142) | 0.727 |
INSL3 | RXFP1 | ENSP00000321724 | ENSP00000303248 | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | relaxin/insulin-like family peptide receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP | 0.961 |
INSL3 | RXFP2 | ENSP00000321724 | ENSP00000298386 | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | relaxin/insulin-like family peptide receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) | 0.995 |
INSL3 | RXFP3 | ENSP00000321724 | ENSP00000328708 | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | relaxin/insulin-like family peptide receptor 3; Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation | 0.636 |
INSL3 | RXFP4 | ENSP00000321724 | ENSP00000357301 | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | relaxin/insulin-like family peptide receptor 4; High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation | 0.708 |
INSL4 | INSL3 | ENSP00000239316 | ENSP00000321724 | insulin-like 4 (placenta); May play an important role in trophoblast development and in the regulation of bone formation | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | 0.750 |
INSL4 | INSL5 | ENSP00000239316 | ENSP00000302724 | insulin-like 4 (placenta); May play an important role in trophoblast development and in the regulation of bone formation | insulin-like 5; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor | 0.701 |
INSL4 | RLN1 | ENSP00000239316 | ENSP00000223862 | insulin-like 4 (placenta); May play an important role in trophoblast development and in the regulation of bone formation | relaxin 1; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix | 0.752 |
INSL4 | RLN2 | ENSP00000239316 | ENSP00000371040 | insulin-like 4 (placenta); May play an important role in trophoblast development and in the regulation of bone formation | relaxin 2; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix | 0.580 |
INSL4 | RLN3 | ENSP00000239316 | ENSP00000397415 | insulin-like 4 (placenta); May play an important role in trophoblast development and in the regulation of bone formation | relaxin 3; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142) | 0.700 |
INSL4 | RXFP1 | ENSP00000239316 | ENSP00000303248 | insulin-like 4 (placenta); May play an important role in trophoblast development and in the regulation of bone formation | relaxin/insulin-like family peptide receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP | 0.585 |
INSL4 | RXFP2 | ENSP00000239316 | ENSP00000298386 | insulin-like 4 (placenta); May play an important role in trophoblast development and in the regulation of bone formation | relaxin/insulin-like family peptide receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) | 0.580 |
INSL4 | RXFP3 | ENSP00000239316 | ENSP00000328708 | insulin-like 4 (placenta); May play an important role in trophoblast development and in the regulation of bone formation | relaxin/insulin-like family peptide receptor 3; Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation | 0.510 |
INSL4 | RXFP4 | ENSP00000239316 | ENSP00000357301 | insulin-like 4 (placenta); May play an important role in trophoblast development and in the regulation of bone formation | relaxin/insulin-like family peptide receptor 4; High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation | 0.585 |
INSL5 | INSL3 | ENSP00000302724 | ENSP00000321724 | insulin-like 5; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | 0.701 |