| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARF1 | CDKN2A | ENSP00000272102 | ENSP00000394932 | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] | cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein | 0.709 |
| ARF1 | PLEKHA8 | ENSP00000272102 | ENSP00000397947 | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8; Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for [...] | 0.787 |
| ARF1 | TOM1L1 | ENSP00000272102 | ENSP00000460823 | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] | target of myb1 (chicken)-like 1; Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity) | 0.531 |
| CDKN2A | ARF1 | ENSP00000394932 | ENSP00000272102 | cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] | 0.709 |
| CDKN2A | PLEKHA8 | ENSP00000394932 | ENSP00000397947 | cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8; Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for [...] | 0.752 |
| CEL | PLEKHA8 | ENSP00000361151 | ENSP00000397947 | carboxyl ester lipase (bile salt-stimulated lipase); Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8; Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for [...] | 0.860 |
| EFCAB1 | METTL6 | ENSP00000262103 | ENSP00000373300 | EF-hand calcium binding domain 1 | methyltransferase like 6; Probable methyltransferase (By similarity) | 0.761 |
| EFCAB1 | PLEKHA8 | ENSP00000262103 | ENSP00000397947 | EF-hand calcium binding domain 1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8; Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for [...] | 0.707 |
| ENPEP | LHFPL3 | ENSP00000265162 | ENSP00000444350 | glutamyl aminopeptidase (aminopeptidase A); Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells | lipoma HMGIC fusion partner-like 3 | 0.484 |
| ENPEP | LHFPL4 | ENSP00000265162 | ENSP00000287585 | glutamyl aminopeptidase (aminopeptidase A); Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells | lipoma HMGIC fusion partner-like 4 | 0.482 |
| ENPEP | PLEKHA8 | ENSP00000265162 | ENSP00000397947 | glutamyl aminopeptidase (aminopeptidase A); Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8; Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for [...] | 0.601 |
| ENPEP | SEC63 | ENSP00000265162 | ENSP00000357998 | glutamyl aminopeptidase (aminopeptidase A); Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells | SEC63 homolog (S. cerevisiae); Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane | 0.569 |
| ENPEP | TOM1L1 | ENSP00000265162 | ENSP00000460823 | glutamyl aminopeptidase (aminopeptidase A); Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells | target of myb1 (chicken)-like 1; Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity) | 0.590 |
| LHFPL3 | ENPEP | ENSP00000444350 | ENSP00000265162 | lipoma HMGIC fusion partner-like 3 | glutamyl aminopeptidase (aminopeptidase A); Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells | 0.484 |
| LHFPL3 | PLEKHA8 | ENSP00000444350 | ENSP00000397947 | lipoma HMGIC fusion partner-like 3 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8; Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for [...] | 0.614 |
| LHFPL3 | SEC63 | ENSP00000444350 | ENSP00000357998 | lipoma HMGIC fusion partner-like 3 | SEC63 homolog (S. cerevisiae); Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane | 0.544 |
| LHFPL3 | TOM1L1 | ENSP00000444350 | ENSP00000460823 | lipoma HMGIC fusion partner-like 3 | target of myb1 (chicken)-like 1; Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity) | 0.527 |
| LHFPL4 | ENPEP | ENSP00000287585 | ENSP00000265162 | lipoma HMGIC fusion partner-like 4 | glutamyl aminopeptidase (aminopeptidase A); Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells | 0.482 |
| LHFPL4 | PLEKHA8 | ENSP00000287585 | ENSP00000397947 | lipoma HMGIC fusion partner-like 4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8; Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for [...] | 0.629 |
| LHFPL4 | SEC63 | ENSP00000287585 | ENSP00000357998 | lipoma HMGIC fusion partner-like 4 | SEC63 homolog (S. cerevisiae); Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane | 0.542 |
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