Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | TTC21A | tetratricopeptide repeat domain 21A (1320 aa) | ||||||||||||
Predicted Functional Partners:
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 | CCDC113 | coiled-coil domain containing 113 (377 aa) |
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0.705 | ||||||||||
 | TTC18 | tetratricopeptide repeat domain 18 (1121 aa) |
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0.698 | ||||||||||
 | CCDC65 | coiled-coil domain containing 65 (484 aa) |
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0.694 | ||||||||||
 | WDR66 | WD repeat domain 66 (1149 aa) |
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0.674 | ||||||||||
 | CCDC39 | coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly (941 aa) |
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0.580 | ||||||||||
 | STIP1 | stress-induced-phosphoprotein 1; Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB) (543 aa) |
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0.567 | ||||||||||
 | LRRC3B | leucine rich repeat containing 3B (259 aa) |
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0.508 | ||||||||||
 | LRCH4 | leucine-rich repeats and calponin homology (CH) domain containing 4 (683 aa) |
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0.501 | ||||||||||
 | C6orf165 | chromosome 6 open reading frame 165 (622 aa) |
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0.495 | ||||||||||
 | TCTEX1D2 | Tctex1 domain containing 2 (142 aa) |
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0.495 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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