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MITF MITF RPE65 RPE65 C11orf9 C11orf9 PRPH2 PRPH2 BEST1 BEST1 ANO1 ANO1 ANO2 ANO2 CFTR CFTR TTYH3 TTYH3 CLCN2 CLCN2 TTYH2 TTYH2
"BEST1" - bestrophin 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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experimentally determined
Predicted Interactions
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Score
BEST1bestrophin 1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate (604 aa)    
Predicted Functional Partners:
MITF
microphthalmia-associated transcription factor (520 aa)
            score_image   0.894
ANO1
anoctamin 1, calcium activated chloride channel; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development (986 aa)
          score_image score_image   0.789
C11orf9
chromosome 11 open reading frame 9; Transcription regulator required for expression of CNS myelin genes such as Mbp, Mog, Mag and Plp1 thereby playing a central role in oligodendrocyte maturation and central nervous system (CNS) myelination. It is not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (By similarity) (1151 aa)
            score_image   0.750
PRPH2
peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis (346 aa)
            score_image   0.740
TTYH3
tweety homolog 3 (Drosophila); Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction (523 aa)
          score_image score_image   0.728
ANO2
anoctamin 2; Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina (998 aa)
          score_image score_image   0.723
CLCN2
chloride channel, voltage-sensitive 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport (898 aa)
          score_image score_image   0.666
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (1480 aa)
          score_image score_image   0.647
TTYH2
tweety homolog 2 (Drosophila); Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation (534 aa)
          score_image score_image   0.645
RPE65
retinal pigment epithelium-specific protein 65kDa; Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis- retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of th [...] (533 aa)
            score_image   0.637
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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