FAM65A protein (Homo sapiens) - STRING network view

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FAM65A

family with sequence similarity 65, member A; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...] (1239 aa)

Predicted Functional Partners:

PLEKHH2

0.597

SH2D4A

0.597

EHD3

0.582

PLEKHH1

0.489

SH2D4B

0.487

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EHD3	FAM65A	ENSP00000327116	ENSP00000400099	EH-domain containing 3; Plays a role in endocytic transport	family with sequence similarity 65, member A; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...]	0.582
EHD3	PLEKHH1	ENSP00000327116	ENSP00000330278	EH-domain containing 3; Plays a role in endocytic transport	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	0.405
EHD3	PLEKHH2	ENSP00000327116	ENSP00000282406	EH-domain containing 3; Plays a role in endocytic transport	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2; In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia	0.739
EHD3	SH2D4A	ENSP00000327116	ENSP00000265807	EH-domain containing 3; Plays a role in endocytic transport	SH2 domain containing 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function	0.717
EHD3	SH2D4B	ENSP00000327116	ENSP00000345295	EH-domain containing 3; Plays a role in endocytic transport	SH2 domain containing 4B	0.467
FAM65A	EHD3	ENSP00000400099	ENSP00000327116	family with sequence similarity 65, member A; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...]	EH-domain containing 3; Plays a role in endocytic transport	0.582
FAM65A	PLEKHH1	ENSP00000400099	ENSP00000330278	family with sequence similarity 65, member A; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...]	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	0.489
FAM65A	PLEKHH2	ENSP00000400099	ENSP00000282406	family with sequence similarity 65, member A; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...]	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2; In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia	0.597
FAM65A	SH2D4A	ENSP00000400099	ENSP00000265807	family with sequence similarity 65, member A; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...]	SH2 domain containing 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function	0.597
FAM65A	SH2D4B	ENSP00000400099	ENSP00000345295	family with sequence similarity 65, member A; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...]	SH2 domain containing 4B	0.487
PLEKHH1	EHD3	ENSP00000330278	ENSP00000327116	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	EH-domain containing 3; Plays a role in endocytic transport	0.405
PLEKHH1	FAM65A	ENSP00000330278	ENSP00000400099	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	family with sequence similarity 65, member A; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...]	0.489
PLEKHH1	SH2D4A	ENSP00000330278	ENSP00000265807	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	SH2 domain containing 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function	0.596
PLEKHH1	SH2D4B	ENSP00000330278	ENSP00000345295	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	SH2 domain containing 4B	0.596
PLEKHH2	EHD3	ENSP00000282406	ENSP00000327116	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2; In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia	EH-domain containing 3; Plays a role in endocytic transport	0.739
PLEKHH2	FAM65A	ENSP00000282406	ENSP00000400099	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2; In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia	family with sequence similarity 65, member A; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...]	0.597
PLEKHH2	SH2D4A	ENSP00000282406	ENSP00000265807	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2; In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia	SH2 domain containing 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function	0.874
PLEKHH2	SH2D4B	ENSP00000282406	ENSP00000345295	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2; In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia	SH2 domain containing 4B	0.596
SH2D4A	EHD3	ENSP00000265807	ENSP00000327116	SH2 domain containing 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function	EH-domain containing 3; Plays a role in endocytic transport	0.717
SH2D4A	FAM65A	ENSP00000265807	ENSP00000400099	SH2 domain containing 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function	family with sequence similarity 65, member A; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...]	0.597

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