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ABL1 ABL1 ABL2 ABL2 TRIM44 TRIM44 FAT1 FAT1 FJX1 FJX1 FAT4 FAT4 DCHS1 DCHS1 VANGL2 VANGL2 COMMD9 COMMD9 FAT2 FAT2 FAT3 FAT3
"FJX1" - four jointed box 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
FJX1four jointed box 1 (Drosophila); Acts as an inhibitor of dendrite extension and branching (By similarity) (437 aa)    
Predicted Functional Partners:
FAT4
FAT tumor suppressor homolog 4 (Drosophila); May function in the regulation of planar cell polarity (By similarity). Cadherins are cell-cell interaction molecules (By similarity) (4981 aa)
        score_image   score_image   0.977
COMMD9
COMM domain containing 9 (198 aa)
            score_image   0.865
TRIM44
tripartite motif containing 44; May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17 (344 aa)
            score_image   0.860
DCHS1
dachsous 1 (Drosophila); Calcium-dependent cell-adhesion protein (Potential) (3298 aa)
        score_image   score_image   0.765
FAT2
FAT tumor suppressor homolog 2 (Drosophila); Plays a role in the migration of epidermal cells. May modulate the extracellular space surronding parallel fibers of cerebellar during development (By similarity) (4349 aa)
        score_image   score_image   0.748
VANGL2
vang-like 2 (van gogh, Drosophila); Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process (By similarity) (521 aa)
            score_image   0.731
FAT1
FAT tumor suppressor homolog 1 (Drosophila); Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact (By similarity) (4588 aa)
        score_image   score_image   0.719
FAT3
FAT tumor suppressor homolog 3 (Drosophila); May play a role in the interactions between neurites derived from specific subsets of neurons during development (By similarity) (4589 aa)
        score_image   score_image   0.719
ABL2
v-abl Abelson murine leukemia viral oncogene homolog 2 (1182 aa)
            score_image   0.707
ABL1
c-abl oncogene 1, non-receptor tyrosine kinase; Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN ( [...] (1149 aa)
            score_image   0.707
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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