FASTKD1 protein (Homo sapiens) - STRING network view

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FASTKD1

FAST kinase domains 1 (847 aa)

Predicted Functional Partners:

CDKL2

0.608

ATG14

0.575

TEAD4

0.543

ATRN

0.512

TEAD1

0.506

TEAD3

0.506

BAZ2B

0.497

UBC

0.483

VPS16

0.474

TEAD2

0.472

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG14	CDKL2	ENSP00000247178	ENSP00000412365	autophagy related 14; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner	cyclin-dependent kinase-like 2 (CDC2-related kinase)	0.516
ATG14	FASTKD1	ENSP00000247178	ENSP00000400513	autophagy related 14; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner	FAST kinase domains 1	0.575
ATRN	FASTKD1	ENSP00000262919	ENSP00000400513	attractin	FAST kinase domains 1	0.512
ATRN	UBC	ENSP00000262919	ENSP00000344818	attractin	ubiquitin C	0.620
BAZ2B	FASTKD1	ENSP00000376534	ENSP00000400513	bromodomain adjacent to zinc finger domain, 2B; May play a role in transcriptional regulation interacting with ISWI	FAST kinase domains 1	0.497
CDKL2	ATG14	ENSP00000412365	ENSP00000247178	cyclin-dependent kinase-like 2 (CDC2-related kinase)	autophagy related 14; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner	0.516
CDKL2	FASTKD1	ENSP00000412365	ENSP00000400513	cyclin-dependent kinase-like 2 (CDC2-related kinase)	FAST kinase domains 1	0.608
FASTKD1	ATG14	ENSP00000400513	ENSP00000247178	FAST kinase domains 1	autophagy related 14; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner	0.575
FASTKD1	ATRN	ENSP00000400513	ENSP00000262919	FAST kinase domains 1	attractin	0.512
FASTKD1	BAZ2B	ENSP00000400513	ENSP00000376534	FAST kinase domains 1	bromodomain adjacent to zinc finger domain, 2B; May play a role in transcriptional regulation interacting with ISWI	0.497
FASTKD1	CDKL2	ENSP00000400513	ENSP00000412365	FAST kinase domains 1	cyclin-dependent kinase-like 2 (CDC2-related kinase)	0.608
FASTKD1	TEAD1	ENSP00000400513	ENSP00000354588	FAST kinase domains 1	TEA domain family member 1 (SV40 transcriptional enhancer factor); Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/ [...]	0.506
FASTKD1	TEAD2	ENSP00000400513	ENSP00000310701	FAST kinase domains 1	TEA domain family member 2; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferat [...]	0.472
FASTKD1	TEAD3	ENSP00000400513	ENSP00000345772	FAST kinase domains 1	TEA domain family member 3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferat [...]	0.506
FASTKD1	TEAD4	ENSP00000400513	ENSP00000352926	FAST kinase domains 1	TEA domain family member 4; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferat [...]	0.543
FASTKD1	UBC	ENSP00000400513	ENSP00000344818	FAST kinase domains 1	ubiquitin C	0.483
FASTKD1	VPS16	ENSP00000400513	ENSP00000369810	FAST kinase domains 1	vacuolar protein sorting 16 homolog (S. cerevisiae); May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes	0.474
TEAD1	FASTKD1	ENSP00000354588	ENSP00000400513	TEA domain family member 1 (SV40 transcriptional enhancer factor); Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/ [...]	FAST kinase domains 1	0.506
TEAD1	TEAD2	ENSP00000354588	ENSP00000310701	TEA domain family member 1 (SV40 transcriptional enhancer factor); Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/ [...]	TEA domain family member 2; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferat [...]	0.902
TEAD1	TEAD3	ENSP00000354588	ENSP00000345772	TEA domain family member 1 (SV40 transcriptional enhancer factor); Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/ [...]	TEA domain family member 3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferat [...]	0.901

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