CASP16 protein (Homo sapiens) - STRING network view

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CASP16

caspase 16, apoptosis-related cysteine peptidase (putative) (183 aa)

Predicted Functional Partners:

CCDC105

0.705

APAF1

0.689

SLC25A38

0.485

ZNF213

0.475

ENSG00000258643

0.474

BCL2A1

0.419

MCL1

0.407

BAK1

0.407

BCL2

0.407

BOK

0.407

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BAK1	ENSP00000448165	ENSP00000353878	apoptotic peptidase activating factor 1	BCL2-antagonist/killer 1; In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis	0.997
APAF1	BCL2	ENSP00000448165	ENSP00000329623	apoptotic peptidase activating factor 1	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	0.999
APAF1	BCL2A1	ENSP00000448165	ENSP00000267953	apoptotic peptidase activating factor 1	BCL2-related protein A1; Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity)	0.912
APAF1	BOK	ENSP00000448165	ENSP00000314132	apoptotic peptidase activating factor 1	BCL2-related ovarian killer; May play a role in apoptosis	0.890
APAF1	CASP16	ENSP00000448165	ENSP00000400592	apoptotic peptidase activating factor 1	caspase 16, apoptosis-related cysteine peptidase (putative)	0.689
APAF1	ENSG00000258643	ENSP00000448165	ENSP00000451320	apoptotic peptidase activating factor 1	BCL2L2-PABPN1 readthrough; Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX	0.948
APAF1	MCL1	ENSP00000448165	ENSP00000358022	apoptotic peptidase activating factor 1	myeloid cell leukemia sequence 1 (BCL2-related)	0.950
BAK1	APAF1	ENSP00000353878	ENSP00000448165	BCL2-antagonist/killer 1; In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis	apoptotic peptidase activating factor 1	0.997
BAK1	BCL2	ENSP00000353878	ENSP00000329623	BCL2-antagonist/killer 1; In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	0.999
BAK1	BCL2A1	ENSP00000353878	ENSP00000267953	BCL2-antagonist/killer 1; In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis	BCL2-related protein A1; Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity)	0.987
BAK1	BOK	ENSP00000353878	ENSP00000314132	BCL2-antagonist/killer 1; In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis	BCL2-related ovarian killer; May play a role in apoptosis	0.561
BAK1	CASP16	ENSP00000353878	ENSP00000400592	BCL2-antagonist/killer 1; In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis	caspase 16, apoptosis-related cysteine peptidase (putative)	0.407
BAK1	MCL1	ENSP00000353878	ENSP00000358022	BCL2-antagonist/killer 1; In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis	myeloid cell leukemia sequence 1 (BCL2-related)	0.999
BCL2	APAF1	ENSP00000329623	ENSP00000448165	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	apoptotic peptidase activating factor 1	0.999
BCL2	BAK1	ENSP00000329623	ENSP00000353878	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	BCL2-antagonist/killer 1; In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis	0.999
BCL2	BCL2A1	ENSP00000329623	ENSP00000267953	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	BCL2-related protein A1; Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity)	0.925
BCL2	BOK	ENSP00000329623	ENSP00000314132	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	BCL2-related ovarian killer; May play a role in apoptosis	0.484
BCL2	CASP16	ENSP00000329623	ENSP00000400592	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	caspase 16, apoptosis-related cysteine peptidase (putative)	0.407
BCL2	MCL1	ENSP00000329623	ENSP00000358022	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	myeloid cell leukemia sequence 1 (BCL2-related)	0.986
BCL2A1	APAF1	ENSP00000267953	ENSP00000448165	BCL2-related protein A1; Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity)	apoptotic peptidase activating factor 1	0.912

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