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ENSG00000268412 ENSG00000268412 TRMT112 TRMT112 RRS1 RRS1 WBSCR22 WBSCR22 NIP7 NIP7 NSUN6 NSUN6 PPAN PPAN RPF1 RPF1 PES1 PES1 ENSG00000243207 ENSG00000243207 BYSL BYSL
"WBSCR22" - Williams Beuren syndrome chromosome region 22 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
WBSCR22Williams Beuren syndrome chromosome region 22 (298 aa)    
Predicted Functional Partners:
TRMT112
tRNA methyltransferase 11-2 homolog (S. cerevisiae); Participates both in methylation of protein and tRNA species. The heterodimer with HEMK2/N6AMT1 catalyzes N5- methylation of ETF1 on ’Gln-185’, using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (125 aa)
      score_image score_image   score_image   0.834
BYSL
bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos (437 aa)
      score_image score_image       0.819
ENSG00000268412
Uncharacterized protein (135 aa)
      score_image score_image   score_image   0.814
RPF1
ribosome production factor 1 homolog (S. cerevisiae); May be required for ribosome biogenesis (349 aa)
      score_image         0.752
RRS1
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae); Involved in ribosome biogenesis (By similarity) (365 aa)
      score_image         0.741
NSUN6
NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) (469 aa)
      score_image     score_image   0.739
PPAN
peter pan homolog (Drosophila); Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP (794 aa)
      score_image         0.735
ENSG00000243207
PPAN-P2RY11 readthrough (794 aa)
      score_image         0.735
PES1
pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome (588 aa)
      score_image         0.734
NIP7
nuclear import 7 homolog (S. cerevisiae); Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly (180 aa)
      score_image         0.734
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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