DAZ4 protein (Homo sapiens) - STRING network view

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DAZ4

deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation (579 aa)

Predicted Functional Partners:

DAZAP2

0.959

PUM2

0.913

DZIP1

0.893

DZIP3

0.848

TSPY10

0.728

CDY1B

0.728

CDY1

0.728

TSPY1

0.727

USP9Y

0.720

QKI

0.704

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDY1	DAZ4	ENSP00000302968	ENSP00000401363	chromodomain protein, Y-linked, 1; Has histone acetyltransferase activity, with a preference for histone H4	deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation	0.728
CDY1	TSPY1	ENSP00000302968	ENSP00000403304	chromodomain protein, Y-linked, 1; Has histone acetyltransferase activity, with a preference for histone H4	testis specific protein, Y-linked 1; May be involved in sperm differentiation and proliferation	0.667
CDY1	TSPY10	ENSP00000302968	ENSP00000406407	chromodomain protein, Y-linked, 1; Has histone acetyltransferase activity, with a preference for histone H4	testis specific protein, Y-linked 10; Unknown. May be involved in sperm differentiation and proliferation (By similarity)	0.670
CDY1	USP9Y	ENSP00000302968	ENSP00000342812	chromodomain protein, Y-linked, 1; Has histone acetyltransferase activity, with a preference for histone H4	ubiquitin specific peptidase 9, Y-linked; May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex w [...]	0.705
CDY1B	DAZ4	ENSP00000303178	ENSP00000401363	chromodomain protein, Y-linked, 1B; Has histone acetyltransferase activity, with a preference for histone H4	deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation	0.728
CDY1B	TSPY1	ENSP00000303178	ENSP00000403304	chromodomain protein, Y-linked, 1B; Has histone acetyltransferase activity, with a preference for histone H4	testis specific protein, Y-linked 1; May be involved in sperm differentiation and proliferation	0.667
CDY1B	TSPY10	ENSP00000303178	ENSP00000406407	chromodomain protein, Y-linked, 1B; Has histone acetyltransferase activity, with a preference for histone H4	testis specific protein, Y-linked 10; Unknown. May be involved in sperm differentiation and proliferation (By similarity)	0.670
CDY1B	USP9Y	ENSP00000303178	ENSP00000342812	chromodomain protein, Y-linked, 1B; Has histone acetyltransferase activity, with a preference for histone H4	ubiquitin specific peptidase 9, Y-linked; May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex w [...]	0.706
DAZ4	CDY1	ENSP00000401363	ENSP00000302968	deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation	chromodomain protein, Y-linked, 1; Has histone acetyltransferase activity, with a preference for histone H4	0.728
DAZ4	CDY1B	ENSP00000401363	ENSP00000303178	deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation	chromodomain protein, Y-linked, 1B; Has histone acetyltransferase activity, with a preference for histone H4	0.728
DAZ4	DAZAP2	ENSP00000401363	ENSP00000448051	deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation	DAZ associated protein 2	0.959
DAZ4	DZIP1	ENSP00000401363	ENSP00000257312	deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation	DAZ interacting protein 1; May participate in spermatogenesis via its interaction with DAZ	0.893
DAZ4	DZIP3	ENSP00000401363	ENSP00000355028	deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation	DAZ interacting protein 3, zinc finger	0.848
DAZ4	PUM2	ENSP00000401363	ENSP00000338173	deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation	pumilio homolog 2 (Drosophila); Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3’-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts	0.913
DAZ4	QKI	ENSP00000401363	ENSP00000355094	deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation	QKI, KH domain containing, RNA binding	0.704
DAZ4	TSPY1	ENSP00000401363	ENSP00000403304	deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation	testis specific protein, Y-linked 1; May be involved in sperm differentiation and proliferation	0.727
DAZ4	TSPY10	ENSP00000401363	ENSP00000406407	deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation	testis specific protein, Y-linked 10; Unknown. May be involved in sperm differentiation and proliferation (By similarity)	0.728
DAZ4	USP9Y	ENSP00000401363	ENSP00000342812	deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation	ubiquitin specific peptidase 9, Y-linked; May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex w [...]	0.720
DAZAP2	DAZ4	ENSP00000448051	ENSP00000401363	DAZ associated protein 2	deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation	0.959
DZIP1	DAZ4	ENSP00000257312	ENSP00000401363	DAZ interacting protein 1; May participate in spermatogenesis via its interaction with DAZ	deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation	0.893

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