node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLIP1 | DCTN1 | ENSP00000303585 | ENSP00000354791 | CAP-GLY domain containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking | dynactin 1 | 0.999 |
CLIP1 | DNAH1 | ENSP00000303585 | ENSP00000401514 | CAP-GLY domain containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking | dynein, axonemal, heavy chain 1 | 0.952 |
CLIP1 | DNAH3 | ENSP00000303585 | ENSP00000261383 | CAP-GLY domain containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking | dynein, axonemal, heavy chain 3 | 0.952 |
CLIP1 | DNAH5 | ENSP00000303585 | ENSP00000265104 | CAP-GLY domain containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking | dynein, axonemal, heavy chain 5; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles | 0.952 |
CLIP1 | DNAH7 | ENSP00000303585 | ENSP00000311273 | CAP-GLY domain containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking | dynein, axonemal, heavy chain 7 | 0.541 |
CLIP1 | PAFAH1B1 | ENSP00000303585 | ENSP00000380378 | CAP-GLY domain containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated [...] | 0.990 |
DCTN1 | CLIP1 | ENSP00000354791 | ENSP00000303585 | dynactin 1 | CAP-GLY domain containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking | 0.999 |
DCTN1 | DNAH1 | ENSP00000354791 | ENSP00000401514 | dynactin 1 | dynein, axonemal, heavy chain 1 | 0.964 |
DCTN1 | DNAH14 | ENSP00000354791 | ENSP00000383737 | dynactin 1 | dynein, axonemal, heavy chain 14 | 0.540 |
DCTN1 | DNAH3 | ENSP00000354791 | ENSP00000261383 | dynactin 1 | dynein, axonemal, heavy chain 3 | 0.962 |
DCTN1 | DNAH5 | ENSP00000354791 | ENSP00000265104 | dynactin 1 | dynein, axonemal, heavy chain 5; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles | 0.962 |
DCTN1 | DNAH7 | ENSP00000354791 | ENSP00000311273 | dynactin 1 | dynein, axonemal, heavy chain 7 | 0.827 |
DCTN1 | DYNC1LI1 | ENSP00000354791 | ENSP00000273130 | dynactin 1 | dynein, cytoplasmic 1, light intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress throuh the spindle assembly check [...] | 0.796 |
DCTN1 | DYNLL1 | ENSP00000354791 | ENSP00000242577 | dynactin 1 | dynein, light chain, LC8-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures | 0.962 |
DCTN1 | DYNLT3 | ENSP00000354791 | ENSP00000367841 | dynactin 1 | dynein, light chain, Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity) | 0.682 |
DCTN1 | PAFAH1B1 | ENSP00000354791 | ENSP00000380378 | dynactin 1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated [...] | 0.995 |
DNAH1 | CLIP1 | ENSP00000401514 | ENSP00000303585 | dynein, axonemal, heavy chain 1 | CAP-GLY domain containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking | 0.952 |
DNAH1 | DCTN1 | ENSP00000401514 | ENSP00000354791 | dynein, axonemal, heavy chain 1 | dynactin 1 | 0.964 |
DNAH1 | DNAH14 | ENSP00000401514 | ENSP00000383737 | dynein, axonemal, heavy chain 1 | dynein, axonemal, heavy chain 14 | 0.932 |
DNAH1 | DNAH3 | ENSP00000401514 | ENSP00000261383 | dynein, axonemal, heavy chain 1 | dynein, axonemal, heavy chain 3 | 0.917 |