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DNAH5 DNAH5 PAFAH1B1 PAFAH1B1 DNAH1 DNAH1 DNAH14 DNAH14 DCTN1 DCTN1 CLIP1 CLIP1 DYNLL1 DYNLL1 DYNLT3 DYNLT3 DNAH3 DNAH3 DNAH7 DNAH7 DYNC1LI1 DYNC1LI1
"DNAH1" - dynein, axonemal, heavy chain 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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second shell of interactors
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experimentally determined
Predicted Interactions
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protein homology
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DNAH1dynein, axonemal, heavy chain 1 (4265 aa)    
Predicted Functional Partners:
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated [...] (410 aa)
        score_image score_image score_image   0.971
DYNLL1
dynein, light chain, LC8-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (89 aa)
        score_image score_image score_image   0.969
DCTN1
dynactin 1 (1278 aa)
      score_image score_image score_image score_image   0.964
CLIP1
CAP-GLY domain containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking (1427 aa)
      score_image score_image score_image score_image   0.952
DYNLT3
dynein, light chain, Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity) (116 aa)
        score_image score_image score_image   0.938
DNAH14
dynein, axonemal, heavy chain 14 (453 aa)
          score_image score_image   0.932
DNAH3
dynein, axonemal, heavy chain 3 (4116 aa)
      score_image   score_image score_image score_image 0.917
DYNC1LI1
dynein, cytoplasmic 1, light intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress throuh the spindle assembly check [...] (523 aa)
        score_image score_image score_image   0.915
DNAH7
dynein, axonemal, heavy chain 7 (4024 aa)
      score_image   score_image score_image score_image 0.914
DNAH5
dynein, axonemal, heavy chain 5; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles (4624 aa)
          score_image score_image score_image 0.913
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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