node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ECD | ELF1 | ENSP00000401566 | ENSP00000239882 | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | E74-like factor 1 (ets domain transcription factor); Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer | 0.762 |
ECD | ELF2 | ENSP00000401566 | ENSP00000265495 | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | E74-like factor 2 (ets domain transcription factor); Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter | 0.762 |
ECD | ELF4 | ENSP00000401566 | ENSP00000311280 | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | E74-like factor 4 (ets domain transcription factor); Transcriptional activator that binds to DNA sequences containing the consensus 5’-WGGA-3’. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and [...] | 0.762 |
ECD | NR1H2 | ENSP00000401566 | ENSP00000253727 | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | nuclear receptor subfamily 1, group H, member 2; Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5’-AGGTCA-3’ and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) | 0.766 |
ECD | NR1H3 | ENSP00000401566 | ENSP00000387946 | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | nuclear receptor subfamily 1, group H, member 3; Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) | 0.766 |
ECD | NR3C1 | ENSP00000401566 | ENSP00000231509 | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); Receptor for glucocorticoids (GC). Has a dual mode of action- as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in [...] | 0.796 |
ECD | PSMC3 | ENSP00000401566 | ENSP00000298852 | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | proteasome (prosome, macropain) 26S subunit, ATPase, 3; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation | 0.902 |
ECD | PSMC5 | ENSP00000401566 | ENSP00000310572 | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | proteasome (prosome, macropain) 26S subunit, ATPase, 5; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex | 0.915 |
ECD | PSMD1 | ENSP00000401566 | ENSP00000309474 | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 0.907 |
ECD | PSMD2 | ENSP00000401566 | ENSP00000310129 | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins | 0.904 |
ELF1 | ECD | ENSP00000239882 | ENSP00000401566 | E74-like factor 1 (ets domain transcription factor); Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | 0.762 |
ELF1 | NR1H2 | ENSP00000239882 | ENSP00000253727 | E74-like factor 1 (ets domain transcription factor); Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer | nuclear receptor subfamily 1, group H, member 2; Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5’-AGGTCA-3’ and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) | 0.416 |
ELF1 | NR1H3 | ENSP00000239882 | ENSP00000387946 | E74-like factor 1 (ets domain transcription factor); Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer | nuclear receptor subfamily 1, group H, member 3; Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) | 0.401 |
ELF2 | ECD | ENSP00000265495 | ENSP00000401566 | E74-like factor 2 (ets domain transcription factor); Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | 0.762 |
ELF2 | NR1H2 | ENSP00000265495 | ENSP00000253727 | E74-like factor 2 (ets domain transcription factor); Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter | nuclear receptor subfamily 1, group H, member 2; Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5’-AGGTCA-3’ and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) | 0.433 |
ELF2 | NR1H3 | ENSP00000265495 | ENSP00000387946 | E74-like factor 2 (ets domain transcription factor); Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter | nuclear receptor subfamily 1, group H, member 3; Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) | 0.403 |
ELF4 | ECD | ENSP00000311280 | ENSP00000401566 | E74-like factor 4 (ets domain transcription factor); Transcriptional activator that binds to DNA sequences containing the consensus 5’-WGGA-3’. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and [...] | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | 0.762 |
ELF4 | NR1H2 | ENSP00000311280 | ENSP00000253727 | E74-like factor 4 (ets domain transcription factor); Transcriptional activator that binds to DNA sequences containing the consensus 5’-WGGA-3’. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and [...] | nuclear receptor subfamily 1, group H, member 2; Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5’-AGGTCA-3’ and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) | 0.416 |
ELF4 | NR1H3 | ENSP00000311280 | ENSP00000387946 | E74-like factor 4 (ets domain transcription factor); Transcriptional activator that binds to DNA sequences containing the consensus 5’-WGGA-3’. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and [...] | nuclear receptor subfamily 1, group H, member 3; Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) | 0.401 |
NR1H2 | ECD | ENSP00000253727 | ENSP00000401566 | nuclear receptor subfamily 1, group H, member 2; Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5’-AGGTCA-3’ and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | 0.766 |