MTO1 protein (Homo sapiens) - STRING network view

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[Homology]

Score

MTO1

mitochondrial translation optimization 1 homolog (S. cerevisiae) (732 aa)

Predicted Functional Partners:

GTPBP3

0.999

TRMU

0.944

UBC

0.797

TOP2A

0.733

TOP2B

0.723

OXA1L

0.641

MRPL34

0.627

MT-ATP6

0.626

COX18

0.624

PRDM10

0.623

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COX18	GTPBP3	ENSP00000295890	ENSP00000351644	cytochrome c oxidase assembly homolog 18 (yeast); Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space	GTP binding protein 3 (mitochondrial)	0.629
COX18	MRPL34	ENSP00000295890	ENSP00000252602	cytochrome c oxidase assembly homolog 18 (yeast); Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space	mitochondrial ribosomal protein L34	0.686
COX18	MT-ATP6	ENSP00000295890	ENSP00000354632	cytochrome c oxidase assembly homolog 18 (yeast); Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space	mitochondrially encoded ATP synthase 6	0.693
COX18	MTO1	ENSP00000295890	ENSP00000402038	cytochrome c oxidase assembly homolog 18 (yeast); Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space	mitochondrial translation optimization 1 homolog (S. cerevisiae)	0.624
COX18	TOP2A	ENSP00000295890	ENSP00000411532	cytochrome c oxidase assembly homolog 18 (yeast); Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space	topoisomerase (DNA) II alpha 170kDa	0.649
COX18	TOP2B	ENSP00000295890	ENSP00000396704	cytochrome c oxidase assembly homolog 18 (yeast); Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space	topoisomerase (DNA) II beta 180kDa; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene	0.649
GTPBP3	COX18	ENSP00000351644	ENSP00000295890	GTP binding protein 3 (mitochondrial)	cytochrome c oxidase assembly homolog 18 (yeast); Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space	0.629
GTPBP3	MRPL34	ENSP00000351644	ENSP00000252602	GTP binding protein 3 (mitochondrial)	mitochondrial ribosomal protein L34	0.564
GTPBP3	MTO1	ENSP00000351644	ENSP00000402038	GTP binding protein 3 (mitochondrial)	mitochondrial translation optimization 1 homolog (S. cerevisiae)	0.999
GTPBP3	OXA1L	ENSP00000351644	ENSP00000285848	GTP binding protein 3 (mitochondrial)	oxidase (cytochrome c) assembly 1-like; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria	0.629
GTPBP3	TOP2A	ENSP00000351644	ENSP00000411532	GTP binding protein 3 (mitochondrial)	topoisomerase (DNA) II alpha 170kDa	0.700
GTPBP3	TOP2B	ENSP00000351644	ENSP00000396704	GTP binding protein 3 (mitochondrial)	topoisomerase (DNA) II beta 180kDa; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene	0.700
GTPBP3	TRMU	ENSP00000351644	ENSP00000290846	GTP binding protein 3 (mitochondrial)	tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2- thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base	0.802
GTPBP3	UBC	ENSP00000351644	ENSP00000344818	GTP binding protein 3 (mitochondrial)	ubiquitin C	0.620
MRPL34	COX18	ENSP00000252602	ENSP00000295890	mitochondrial ribosomal protein L34	cytochrome c oxidase assembly homolog 18 (yeast); Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space	0.686
MRPL34	GTPBP3	ENSP00000252602	ENSP00000351644	mitochondrial ribosomal protein L34	GTP binding protein 3 (mitochondrial)	0.564
MRPL34	MTO1	ENSP00000252602	ENSP00000402038	mitochondrial ribosomal protein L34	mitochondrial translation optimization 1 homolog (S. cerevisiae)	0.627
MRPL34	OXA1L	ENSP00000252602	ENSP00000285848	mitochondrial ribosomal protein L34	oxidase (cytochrome c) assembly 1-like; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria	0.686
MRPL34	TOP2A	ENSP00000252602	ENSP00000411532	mitochondrial ribosomal protein L34	topoisomerase (DNA) II alpha 170kDa	0.543
MRPL34	TOP2B	ENSP00000252602	ENSP00000396704	mitochondrial ribosomal protein L34	topoisomerase (DNA) II beta 180kDa; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene	0.545

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