node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCL6 | HDAC1 | ENSP00000232014 | ENSP00000362649 | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium s [...] | 0.990 |
BCL6 | NCOR1 | ENSP00000232014 | ENSP00000268712 | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors | 0.997 |
BCL6 | NCOR2 | ENSP00000232014 | ENSP00000384018 | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | nuclear receptor corepressor 2; Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors | 0.999 |
BCL6 | RUNX1 | ENSP00000232014 | ENSP00000300305 | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | runt-related transcription factor 1 | 0.418 |
BCL6 | RUNX1T1 | ENSP00000232014 | ENSP00000402257 | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.926 |
BCL6 | SIN3A | ENSP00000232014 | ENSP00000353622 | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | SIN3 transcription regulator homolog A (yeast); Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA (By similarity). Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation | 0.924 |
BCL6 | ZBTB16 | ENSP00000232014 | ENSP00000338157 | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | zinc finger and BTB domain containing 16; Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins | 0.694 |
CBFA2T2 | NCOR1 | ENSP00000262653 | ENSP00000268712 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors | 0.885 |
CBFA2T2 | NCOR2 | ENSP00000262653 | ENSP00000384018 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | nuclear receptor corepressor 2; Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors | 0.791 |
CBFA2T2 | RUNX1 | ENSP00000262653 | ENSP00000300305 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | runt-related transcription factor 1 | 0.961 |
CBFA2T2 | RUNX1T1 | ENSP00000262653 | ENSP00000402257 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.945 |
CBFA2T2 | SIN3A | ENSP00000262653 | ENSP00000353622 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | SIN3 transcription regulator homolog A (yeast); Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA (By similarity). Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation | 0.880 |
CEBPA | HDAC1 | ENSP00000427514 | ENSP00000362649 | CCAAT/enhancer binding protein (C/EBP), alpha; C/EBP is a DNA-binding protein that recognizes two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers | histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium s [...] | 0.940 |
CEBPA | NCOR1 | ENSP00000427514 | ENSP00000268712 | CCAAT/enhancer binding protein (C/EBP), alpha; C/EBP is a DNA-binding protein that recognizes two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers | nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors | 0.928 |
CEBPA | NCOR2 | ENSP00000427514 | ENSP00000384018 | CCAAT/enhancer binding protein (C/EBP), alpha; C/EBP is a DNA-binding protein that recognizes two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers | nuclear receptor corepressor 2; Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors | 0.916 |
CEBPA | RUNX1 | ENSP00000427514 | ENSP00000300305 | CCAAT/enhancer binding protein (C/EBP), alpha; C/EBP is a DNA-binding protein that recognizes two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers | runt-related transcription factor 1 | 0.995 |
CEBPA | RUNX1T1 | ENSP00000427514 | ENSP00000402257 | CCAAT/enhancer binding protein (C/EBP), alpha; C/EBP is a DNA-binding protein that recognizes two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.890 |
CEBPA | ZBTB16 | ENSP00000427514 | ENSP00000338157 | CCAAT/enhancer binding protein (C/EBP), alpha; C/EBP is a DNA-binding protein that recognizes two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers | zinc finger and BTB domain containing 16; Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins | 0.675 |
HDAC1 | BCL6 | ENSP00000362649 | ENSP00000232014 | histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium s [...] | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | 0.990 |
HDAC1 | CEBPA | ENSP00000362649 | ENSP00000427514 | histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium s [...] | CCAAT/enhancer binding protein (C/EBP), alpha; C/EBP is a DNA-binding protein that recognizes two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers | 0.940 |