node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AANAT | LAPTM4B | ENSP00000250615 | ENSP00000402301 | aralkylamine N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin | lysosomal protein transmembrane 4 beta | 0.457 |
AANAT | YWHAZ | ENSP00000250615 | ENSP00000309503 | aralkylamine N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.992 |
ABCB1 | LAPTM4B | ENSP00000265724 | ENSP00000402301 | ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells | lysosomal protein transmembrane 4 beta | 0.585 |
C8orf47 | LAPTM4B | ENSP00000315614 | ENSP00000402301 | chromosome 8 open reading frame 47 | lysosomal protein transmembrane 4 beta | 0.483 |
LAPTM4B | AANAT | ENSP00000402301 | ENSP00000250615 | lysosomal protein transmembrane 4 beta | aralkylamine N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin | 0.457 |
LAPTM4B | ABCB1 | ENSP00000402301 | ENSP00000265724 | lysosomal protein transmembrane 4 beta | ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells | 0.585 |
LAPTM4B | C8orf47 | ENSP00000402301 | ENSP00000315614 | lysosomal protein transmembrane 4 beta | chromosome 8 open reading frame 47 | 0.483 |
LAPTM4B | NAALADL2 | ENSP00000402301 | ENSP00000404705 | lysosomal protein transmembrane 4 beta | N-acetylated alpha-linked acidic dipeptidase-like 2; May be catalytically inactive | 0.608 |
LAPTM4B | NEDD4 | ENSP00000402301 | ENSP00000345530 | lysosomal protein transmembrane 4 beta | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.594 |
LAPTM4B | PIK3R1 | ENSP00000402301 | ENSP00000274335 | lysosomal protein transmembrane 4 beta | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.576 |
LAPTM4B | RETSAT | ENSP00000402301 | ENSP00000295802 | lysosomal protein transmembrane 4 beta | retinol saturase (all-trans-retinol 13,14-reductase); Retinol saturase carrying out the saturation of the 13- 14 double bond of all-trans-retinol to produce all-trans-13,14- dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By similarity) | 0.543 |
LAPTM4B | TFRC | ENSP00000402301 | ENSP00000353224 | lysosomal protein transmembrane 4 beta | transferrin receptor (p90, CD71); Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin f [...] | 0.570 |
LAPTM4B | YWHAZ | ENSP00000402301 | ENSP00000309503 | lysosomal protein transmembrane 4 beta | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.590 |
NAALADL2 | LAPTM4B | ENSP00000404705 | ENSP00000402301 | N-acetylated alpha-linked acidic dipeptidase-like 2; May be catalytically inactive | lysosomal protein transmembrane 4 beta | 0.608 |
NEDD4 | LAPTM4B | ENSP00000345530 | ENSP00000402301 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | lysosomal protein transmembrane 4 beta | 0.594 |
NEDD4 | TFRC | ENSP00000345530 | ENSP00000353224 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | transferrin receptor (p90, CD71); Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin f [...] | 0.448 |
NEDD4 | YWHAZ | ENSP00000345530 | ENSP00000309503 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.546 |
PIK3R1 | LAPTM4B | ENSP00000274335 | ENSP00000402301 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | lysosomal protein transmembrane 4 beta | 0.576 |
PIK3R1 | YWHAZ | ENSP00000274335 | ENSP00000309503 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.963 |
RETSAT | LAPTM4B | ENSP00000295802 | ENSP00000402301 | retinol saturase (all-trans-retinol 13,14-reductase); Retinol saturase carrying out the saturation of the 13- 14 double bond of all-trans-retinol to produce all-trans-13,14- dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By similarity) | lysosomal protein transmembrane 4 beta | 0.543 |